1. The Significance of Negative Lymph Nodes in Esophageal Cancer After Curative Resection: A Retrospective Cohort Study
- Author
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Mingwu Chen, Changbo Li, Dongni Chen, and Junxian Mo
- Subjects
0301 basic medicine ,Prognostic factor ,medicine.medical_specialty ,business.industry ,Proportional hazards model ,Retrospective cohort study ,Esophageal cancer ,medicine.disease ,Gastroenterology ,Log-rank test ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Oncology ,Quartile ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,Lymph ,Stage (cooking) ,business - Abstract
Objective The impact of negative lymph nodes (NLNs) count on prognosis in esophageal cancer (EC) was analyzed using two institutions surgical database. Methods We conducted a retrospective study of 768 EC patients treated by surgical resection between January 2010 and December 2012. The effects of the NLNs count on prognosis was analyzed. Cox regression model was conducted to determine the significant prognostic elements. Results The number of NLNs was studied as a categorical variable based on the quartiles (Q1: ≤15, Q2: 16-21, Q3: 22-30, Q4: ≥31). And a better overall survival (OS) was observed with increasing number of NLNs (HR= 0.762; 95% CI, 0.596-0.974 for Q2, HR= 0.666; 95% CI, 0.516-0.860 for Q3 and HR= 0.588; 95% CI, 0.450-0.768 for Q4) (all P
- Published
- 2020