Search

Your search keyword '"Zhi-Wen Xiao"' showing total 2 results
Start Over Author "Zhi-Wen Xiao" Journal cancer letters
2 results on '"Zhi-Wen Xiao"'

1. SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer

Author

Tian-Jiao, Li, Kai-Zhou, Jin, Hao, Li, Long-Yun, Ye, Peng-Cheng, Li, Bruce, Jiang, Xuan, Lin, Zhen-Yu, Liao, Hui-Ru, Zhang, Sai-Meng, Shi, Meng-Xiong, Lin, Qing-Lin, Fei, Zhi-Wen, Xiao, Hua-Xiang, Xu, Liang, Liu, Xian-Jun, Yu, and Wei-Ding, Wu

Subjects
Immunosuppression Therapy, Cancer Research, THP-1 Cells, T-Lymphocytes, Immunoglobulins, Membrane Proteins, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Pancreatic Neoplasms, Mice, Oncology, Cell Line, Tumor, Tumor-Associated Macrophages, Tumor Microenvironment, Animals, Cytokines, Humans, Carcinoma, Pancreatic Ductal
Abstract

Pancreatic ductal adenocarcinoma (PDAC) usually presents infrequent infiltration of T lymphocytes. The known immune-checkpoint inhibitors to date focus on activating T cells and manifest limited effectiveness in PDAC. SIGLEC15 was identified as a novel tumor-associated macrophage (TAM)-related immune-checkpoint in other cancer types, while its immunosuppressive role and clinical significance remained unclear in PDAC. In our study, SIGLEC15 presented immunosuppressive relevance in PDAC via bioinformatic analysis and expressed on TAM and PDAC cells. SIGLEC15

Published
2022

2. Cancer statistics: current diagnosis and treatment of pancreatic cancer in Shanghai, China

Author

Quan Xing Ni, Meng Guo, Liang Liu, Min Li, Chunxiao Wu, Jin Xu, Ying Zheng, Yu tang Gao, Chen Liu, Zu qiang Liu, Jiang Long, Xianjun Yu, Zhi wen Xiao, and Guopei Luo

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, China, Population, Diagnostic modalities, Imaging modalities, Sex Factors, Pancreatic cancer, Medicine, Humans, Shanghai china, education, Cancer death, Aged, education.field_of_study, business.industry, Incidence, Age Factors, Middle Aged, medicine.disease, Surgery, Pancreatic Neoplasms, Oncology, Clinical diagnosis, Case-Control Studies, Female, Radiology, business
Abstract

A multi-center population-based study in Shanghai, China was performed to explore the implications for the management of pancreatic cancer by comparing diagnosis and survival rates. Novel imaging modalities including MRI (13.9%), PET/CT (1.8%), and EUS (5.6%) were not widely used in our population. Only 39.7% of cases were histologically verified (surgery with histologic diagnosis 31.0%, cytological diagnosis 8.7%, surgery without histologic diagnosis 12.1%, and clinical diagnosis 48.2%). Overall, 30.0% of patients underwent curative-intent operation, and only 9.8% of patients received comprehensive treatment. The prognosis of pancreatic cancer patients was significantly better for patients who were treated in high-volume centers than in low-volume centers. We propose that more effort should be put on novel diagnostic modalities, histological confirmation, and comprehensive treatment in China. Multidisciplinary teams specialized in pancreatic cancer therapy in high-volume centers are urgently needed.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results