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Your search keyword '"Yun, Jing"' showing total 9 results
Start Over Author "Yun, Jing" Journal cancer letters
9 results on '"Yun, Jing"'

4. Nucleoporin 93 mediates β-catenin nuclear import to promote hepatocellular carcinoma progression and metastasis

Author

Lin, Cen-Shan, primary, Liang, Yuyi, additional, Su, Shu-Guang, additional, Zheng, Yin-Li, additional, Yang, Xia, additional, Jiang, Neng, additional, Fu, Lingyi, additional, Zhou, Jing, additional, Zhang, Ying, additional, Deng, Ru, additional, Wang, Chun-Hua, additional, Lu, Shi-Xun, additional, Huang, Yu-Hua, additional, Liu, Li-Li, additional, Zhang, Chao, additional, and Yun, Jing-Ping, additional

Published
2022
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6. Corrigendum to “NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma” [Canc. Lett. 476 (2020) 48–56]

Author

Leung, Hoi Wing, primary, Lau, Eunice Yuen Ting, additional, Leung, Carmen Oi Ning, additional, Lei, Martina Mang Leng, additional, Mok, Etienne Ho Kit, additional, Ma, Victor Wan San, additional, Cho, William Chi Shing, additional, Ng, Irene Oi Lin, additional, Yun, Jing Ping, additional, Cai, Shao Hang, additional, Yu, Hua Jian, additional, Ma, Stephanie, additional, and Lee, Terence Kin Wah, additional

Published
2021
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7. NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma

Author

Leung, Hoi Wing, primary, Lau, Eunice Yuen Ting, additional, Leung, Carmen Oi Ning, additional, Lei, Martina Mang Leng, additional, Mok, Etienne Ho Kit, additional, Ma, Victor Wan San, additional, Cho, William Chi Shing, additional, Ng, Irene Oi Lin, additional, Yun, Jing Ping, additional, Cai, Shao Hang, additional, Yu, Hua Jian, additional, Ma, Stephanie, additional, and Lee, Terence Kin Wah, additional

Published
2020
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8. Corrigendum to “Inhibition of the NF-κB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis” [Cancer Lett. 380 (2016) 87–97]

Author

Lu, Yun-Xin, primary, Ju, Huai Qiang, additional, Wang, Feng, additional, Chen, Le-Zong, additional, Wu, Qi-Nian, additional, Sheng, Hui, additional, Mo, Hai-Yu, additional, Pan, Zhi-Zhong, additional, Xie, Dan, additional, Kang, Tie Bang, additional, Chen, Gong, additional, Yun, Jing-Ping, additional, Zeng, Zhao-Lei, additional, and Xu, Rui Hua, additional

Published
2020
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9. NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma.

Author

Wing Leung, Hoi, Ting Lau, Eunice Yuen, Ning Leung, Carmen Oi, Leng Lei, Martina Mang, Kit Mok, Etienne Ho, Ma, Victor Wan San, Shing Cho, William Chi, Lin Ng, Irene Oi, Ping Yun, Jing, Hang Cai, Shao, Jian Yu, Hua, Ma, Stephanie, Wah Lee, Terence Kin, Leung, Hoi Wing, Lau, Eunice Yuen Ting, Leung, Carmen Oi Ning, Lei, Martina Mang Leng, Mok, Etienne Ho Kit, Cho, William Chi Shing, and Ng, Irene Oi Lin

Subjects
*DRUG resistance, *SUBSTANCE abuse relapse, *CELLS, *LIVER
Abstract

Solid evidence shows that tumor-initiating cells (T-ICs) are the root of tumor relapse and drug resistance, which lead to a poor prognosis in patients with hepatocellular carcinoma (HCC). Through an in vitro liver T-IC enrichment approach, we identified nuclear factor (erythroid-derived 2)-like 2 (NRF2) as a transcription regulator that is significantly activated in enriched liver T-IC populations. In human HCCs, NRF2 was found to be overexpressed, which was associated with poor patient survival. Through a lentiviral based knockdown approach, NRF2 was found to be critical for regulating liver T-IC properties, including self-renewal, tumorigenicity, drug resistance and expression of liver T-IC markers. Furthermore, we found that ROS-induced NRF2 activation regulates sorafenib resistance in HCC cells. Mechanistically, NRF2 was found to physically bind to the promoter of sonic hedgehog homolog (SHH), which triggers activation of the sonic hedgehog pathway. The effect of NRF2 knockdown was eliminated upon administration of recombinant SHH, demonstrating that NRF2 mediated T-IC function via upregulation of SHH expression. Our study suggests a novel regulatory mechanism for the canonical sonic hedgehog pathway that may function through the NRF2/SHH/GLI signaling axis, thus mediating T-IC phenotypes. [ABSTRACT FROM AUTHOR]

Published
2020
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