Search

Your search keyword '"Yang, Jiali"' showing total 5 results
Start Over Author "Yang, Jiali" Journal cancer letters
5 results on '"Yang, Jiali"'

3. The dual effects of a novel peptibody on angiogenesis inhibition and M2 macrophage polarization on sarcoma

Author

Wu Chunjing, Xiaoqing Zhu, Yanfeng Gao, Yuanming Qi, Yang Jiali, Guodong Li, and Lili Yi

Subjects
0301 basic medicine, Cancer Research, Immunoconjugates, Angiogenesis, Macrophage polarization, Angiogenesis Inhibitors, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Immune system, Cell Line, Tumor, Tumor Microenvironment, Animals, Humans, Tumor microenvironment, biology, Neovascularization, Pathologic, Chemistry, Macrophages, Macrophage Activation, M2 Macrophage, Fusion protein, Angiopoietin receptor, Immunoglobulin Fc Fragments, 030104 developmental biology, Oncology, Immunoglobulin G, Cancer research, biology.protein, Female, Sarcoma, Experimental, Peptides, Tyrosine kinase
Abstract

Inhibition of the VEGF/VEGF receptor (VEGFR) and angiopoietin-2 (Ang-2)/TEK receptor tyrosine kinase (Tie-2) pathway is a potential target for tumor angiogenesis. We previously showed that a peptide AS16 which dually inhibits VEGFR/Ang-2 could reduce the tumor growth and decrease the number of microvessels in tumor. However, its short circulating half-life in the serum limits its clinical applications. In this study, as an effort to prolong the short in vivo half-life of AS16, we designed a fusion protein containing peptide AS16 and an IgG Fc fragment. Pharmacokinetic study also revealed that AS16-Fc has a prolonged circulating half-life of about 231 min in rats. We examined the effects of treatment on the tumor vasculature and immune cell populations, tumor growth, in both the MCA-205 and S180 tumor models. We found that AS16-Fc dramatically reduced tumor volume, vascular density and tumor-associated macrophages. Macrophages were identified as potential novel targets following anti-angiogenic therapy, our findings imply a novel role for anti-angiogenic peptide AS16-Fc. These findings indicate that AS16-Fc could be more effective on inhibiting tumor growth angiogenesis and tumor immune microenvironment than that of peptide AS16.

Published
2017

5. Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression.

Author

Huang, Wen-Jie, Wang, Yunchao, Liu, Songsong, Yang, Jiali, Guo, Shi-xiang, Wang, Lijiang, Wang, Huaizhi, Fan, Ying-Fang, Wang, Yun-Chao, Liu, Song-Song, Yang, Jia-Li, Wang, Li-Jiang, and Wang, Huai-Zhi

Subjects
*PANCREATIC duct, *ADENOCARCINOMA, *CANCER genetics, *GENE silencing, *CIRCULAR RNA, *CANCER invasiveness, *MICRORNA, *CANCER
Abstract

Circular RNAs (CircRNAs) are a novel type of endogenous noncoding RNAs that regulate target gene expression by interacting with microRNA (miRNA). Emerging evidence shows that dysregulation of circRNAs plays important roles in biological and pathological processes, including cancer development and progression. The functional role of circRNA in PDAC (pancreatic ductal adenocarcinoma) remains to be investigated. In this study, high throughput microarray assay revealed that hsa_circ_0000977 was aberrantly up-regulated in pancreatic cancer tissues; this was also validated by qRT-PCR. Silencing hsa_circ_0000977 suppressed pancreatic cancer cell proliferation and induced cell cycle arrest, which was simulated by hsa-miR-874-3p mimics and blocked by hsa-miR-874-3p inhibitor. Bioinformatics analysis predicted that there is an hsa_circ_0000977/hsa-miR-874-3p/PLK1 (Polo like kinase 1) axis in pancreatic cancer progression. Dual-luciferase reporter system and FISH assay validated the direct interaction of hsa_circ_0000977, hsa-miR-874-3p, and PLK1. Western blot verified that inhibition of hsa_circ_0000977 decreased PLK1 expression. Furthermore, silencing hsa_circ_0000977 suppressed pancreatic cancer growth in vivo. Altogether, silencing hsa_circ_0000977 suppresses progression of pancreatic cancer by interacting with hsa-miR-874-3p and decreasing inhibiting PLK1 expression. Our results may provide a promising strategy for future diagnosis and treatment of pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results