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Start Over Author "Onodera, H." Journal cancer letters
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11. Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver.

Author

Kondo S, Toyokuni S, Tsuruyama T, Ozeki M, Tachibana T, Echizenya M, Hiai H, Onodera H, and Imamura M

Subjects
Adenocarcinoma metabolism, Aged, Apoptosis, Cell Division, Colorectal Neoplasms metabolism, Female, Humans, Immunoenzyme Techniques, Liver Neoplasms metabolism, Male, Middle Aged, Nitric Oxide metabolism, Nitric Oxide Synthase metabolism, Nitric Oxide Synthase Type II, Proliferating Cell Nuclear Antigen metabolism, Reactive Oxygen Species metabolism, Tyrosine metabolism, Adenocarcinoma secondary, Colorectal Neoplasms pathology, Liver Neoplasms secondary, Nitrates pharmacology, Oxidants pharmacology, Oxidative Stress drug effects, Tyrosine analogs & derivatives
Abstract

3-Nitrotyrosine (3-NT), a product of peroxynitrite reaction, is abundantly observed in hepatocytes adjacent to human metastatic colorectal carcinoma. To elucidate its biological significance, we undertook to identify nitric oxide (NO)-producing cells and apoptosis under oxidative stress. We observed strong inducible NO-synthase (iNOS) immunoreactivity in the hepatocytes adjacent to metastatic tumor, revealing an identical pattern to 3-NT immunostaining. Furthermore, intense 3-NT immunostaining of hepatocytes was associated with apoptosis whereas carcinoma cells near those hepatocytes presented high proliferating-cell nuclear antigen. Our results suggest that contact of metastatic tumor induces apoptosis in adjacent hepatocytes through peroxynitrite, thus permitting the proliferation of cancer cells.

Published
2002
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