1. Blocking exposed PD-L1 elicited by nanosecond pulsed electric field reverses dysfunction of CD8
- Author
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Junjie, Qian, Tianchi, Chen, Qinchuan, Wu, Lin, Zhou, Wuhua, Zhou, Liming, Wu, Shuai, Wang, Jiahua, Lu, Wenchao, Wang, Dazhi, Li, Haiyang, Xie, Rong, Su, Danjing, Guo, Zhen, Liu, Ning, He, Shengyong, Yin, and Shusen, Zheng
- Subjects
Liver Neoplasms ,Electric Stimulation Therapy ,CD8-Positive T-Lymphocytes ,Combined Modality Therapy ,Xenograft Model Antitumor Assays ,B7-H1 Antigen ,Mice ,Protein Transport ,Treatment Outcome ,Cell Line, Tumor ,Tumor Microenvironment ,Animals ,Humans ,Immune Checkpoint Inhibitors - Abstract
As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatment increased the level of membrane PD-L1 in liver cancer cells. Furthermore, nsPEF induced the release of PD-L1-associated extra-cellular vesicles, leading to the dysfunction of CD8
- Published
- 2020