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11 results on '"Li, Fei"'

7. Experts’ consensus on intraoperative radiotherapy for pancreatic cancer

Author

Li, Yexiong, primary, Feng, Qinfu, additional, Jin, Jing, additional, Shi, Susheng, additional, Zhang, Zhihui, additional, Che, Xu, additional, Zhang, Jianwei, additional, Chen, Yingtai, additional, Wu, Xiuhong, additional, Chen, Rufu, additional, Li, Shengping, additional, Wang, Jing, additional, Li, Guang, additional, Li, Fei, additional, Dai, Menghua, additional, Zheng, Lei, additional, and Wang, Chengfeng, additional

Published
2019
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9. Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli

Author

Li-Juan Gao, Wen-Jing Huang, Shi-Fang Xu, Yang Wei, Xiaoyu Li, Li-Fei Zhou, Yi-Ping Ye, Wen-Fu Tan, and Feng-Yang Chen

Subjects
0301 basic medicine, Cancer Research, Mutant, medicine.disease_cause, Zinc Finger Protein GLI1, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, parasitic diseases, medicine, Animals, Humans, Hedgehog Proteins, Cerebellar Neoplasms, Hedgehog, Medulloblastoma, Natural product, Cynanchum, Plant Extracts, Phytosterols, medicine.disease, Xenograft Model Antitumor Assays, Hedgehog signaling pathway, 030104 developmental biology, HEK293 Cells, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, NIH 3T3 Cells, Epimer, Signal transduction, Carcinogenesis, Signal Transduction
Abstract

Uncontrolled excessive activation of Hedgehog (Hh) signaling pathway is linked to a number of human malignant tumorigenesis. To obtain valuable Hh pathway inhibitors from natural product, in present study, a pair of novel epimers, Cynanbungeigenin C (CBC) and D (CBD) from the plant Cynanchum bungei Decne were chemically characterized by multiple spectroscopic data and chemical derivatization, and evaluated for their inhibition on Hh pathway. Mechanistically, CBC and CBD block Hh pathway signaling not through targeting Smo and Sufu, but at the level of Gli. In addition, both eipmers significantly suppress Hh pathway-dependent Ptch+/−; p53−/− medulloblastoma in vitro and in vivo. Furthermore, both CBC and CBD inhibited two Smo mutants induced Hh pathway activation, which suggested that they are potential compounds for the treatment of medulloblastoma with primary or acquired resistance to current Smo inhibitors. These results highlight the potential of CBC and CBD as effective lead compounds in the treatment of medulloblastoma and other Hh-dependent malignancy.

Published
2017

11. Corrigendum to “Abrogation of constitutive stat3 activity circumvents cisplatin resistant ovarian cancer” [Cancer Lett. 341 (2013) 231–239]

Author

Ji, Teng, primary, Gong, Danni, additional, Han, Zhiqiang, additional, Wei, Xiao, additional, Yan, Yuting, additional, Ye, Fei, additional, Ding, Wencheng, additional, Wang, Junnai, additional, Xia, Xi, additional, Li, Fei, additional, Hu, Wencheng, additional, Lu, Yunping, additional, Wang, Shixuan, additional, Zhou, Jianfeng, additional, Ma, Ding, additional, and Gao, Qinglei, additional

Published
2014
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