1. Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α
- Author
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Su, Wenjing, Huang, Lei, Ao, Qilin, Zhang, Qinghua, Tian, Xun, Fang, Yong, and Lu, Yunping
- Subjects
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QUINOLINE , *OVARIAN cancer , *CANCER cells , *CISPLATIN , *TRANSCRIPTION factors , *CYTOLOGY , *CELL proliferation - Abstract
Abstract: Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related with chemoresistance of solid tumors. The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1α and sensitize ovarian cancer cells to cisplatin (DDP) under hypoxic conditions. Herein, we report that noscapine sensitized cobalt-induced chemoresistant ovarian cancer cells to DDP-induced apoptosis and inhibition of cell proliferation. Noscapine also promoted proteasome-mediated degradation of cobalt-stabilized HIF-1α protein, with subsequent inhibition of HIF-1 transcriptional activity. These data establish noscapine as a small molecule inhibitor of HIF-1α and provide an evidence for its combination with DDP in combating ovarian cancer chemoresistance. [Copyright &y& Elsevier]
- Published
- 2011
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