1. Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants
- Author
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Thi Hue Hanh Nguyen, Y-Thanh Lu, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Thanh Dat Nguyen, Luu Hong Dang Nguyen, Ngoc Minh Phan, Trong Hieu Nguyen, Van Thien Chi Nguyen, Thi Mong Quynh Pham, Vu Uyen Tran, Minh Phong Le, Dac Ho Vo, Thi Minh Thu Tran, Minh Nguyen Nguyen, Thi Thanh Nguyen, Ba Linh Tieu, Huu Tam Phuc Nguyen, Dinh Yen An Truong, Chi Thuy Tien Cao, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan Anh Luong, Thi Kim Phuong Doan, Thi Trang Dao, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Duy Sinh Nguyen, Thi Quynh Tho Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh-Kiet Truong, Hung Sang Tang, Minh Duy Phan, Hoa Giang, Hoai Nghia Nguyen, and Le Son Tran
- Subjects
Cancer Research ,Oncology ,General Medicine - Abstract
The SPOT-MAS assay “Screening for the Presence Of Tumor by Methylation And Size” detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical trial, K-DETEK. Our analysis of 2795 participants from 14 sites across Vietnam demonstrates its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. We present a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment.
- Published
- 2023
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