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Your search keyword '"Zhang, Xiaomei"' showing total 1 results
Start Over Author "Zhang, Xiaomei" Journal cancer investigation Publisher taylor & francis ltd
1 results on '"Zhang, Xiaomei"'

1. Suppression of Epidermal Growth Factor Receptor (EGFR) Expression by Small Hairpin RNA Inhibits the Growth of Human Nonsmall Cell Lung Cancers Bearing Wild-type and Mutant EGFR.

Author

Zhang, Shuang, Tian, Hongwei, Jiang, Qingyuan, Li, Li, Ding, Yu, Dai, Lei, Xiang, Yu, Shen, Guobo, Cheng, Lin, Huang, Qiaorong, Liu, Yalin, Zhang, Xiaomei, Ma, Yongping, Zhang, Na, Liu, Shengyong, Wang, Wei, Dai, Lixia, Li, Yiming, Zhao, Xia, and Wei, Yuquan

Subjects
EPIDERMAL growth factor, GENE expression, SMALL cell lung cancer, PLASMIDS, LUNG tumors, SMALL interfering RNA, XENOGRAFTS, DRUG resistance in cancer cells
Abstract

In the present study, we have used plasmid-based RNA interference (RNAi) strategy to downregulate the expression of epidermal growth factor receptor (EGFR) in EGFR wild-type (H292) and mutant (H1975) lung tumor models. The targeted knockdown of EGFR by small hairpin RNA not only inhibited growth of H292 xenograft but also inhibited H1975 lung cancer cell and xenograft, which bore L858R/T790M EGFR and was resistant to EGFR tyrosine kinase inhibitors. These data demonstrated that small hairpin RNA was an effective therapy against mutant EGFR-expressing cancer cells and thus considered to be a promising strategy in the treatment of lung cancers. [ABSTRACT FROM AUTHOR]

Published
2011
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