1. der(1)t(1;9): A specific chromosome abnormality in polycythemia vera?
- Author
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Felicia C.T. Havik-Bogaard, H.L. Haak, Christiaan H.W. Leeksma, Jose I. den Nijs van Weert, Geoffrey C. Beverstock, and Tim Kievits
- Subjects
Cancer Research ,medicine.medical_specialty ,Derivative chromosome ,Cytogenetics ,Aneuploidy ,Chromosome 9 ,Chromosomal translocation ,Biology ,medicine.disease ,Molecular biology ,Trisomy 9 ,Polycythemia vera ,hemic and lymphatic diseases ,Genetics ,medicine ,Trisomy ,Molecular Biology - Abstract
Two patients with polycythemia vera and an extra der(1)t(1;9) chromosome are reported. In one patient this was found as the sole abnormality. The other patient originally presented with trisomy 9 but later developed an extra der(1) during the further course of the disease with disappearance of the extra chromosome 9. In situ hybridization studies on this latter patient proved that the centromere of chromosome 1 was involved in the formation of the derivative chromosome.
- Published
- 1989
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