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Your search keyword '"Murray, Liam J."' showing total 12 results
Start Over Author "Murray, Liam J." Journal cancer epidemiology, biomarkers & prevention
12 results on '"Murray, Liam J."'

3. Pleiotropic Analysis of Cancer Risk Loci on Esophageal Adenocarcinoma Risk

Author

Lee, Eunjung, primary, Stram, Daniel O., additional, Ek, Weronica E., additional, Onstad, Lynn E., additional, MacGregor, Stuart, additional, Gharahkhani, Puya, additional, Ye, Weimin, additional, Lagergren, Jesper, additional, Shaheen, Nicholas J., additional, Murray, Liam J., additional, Hardie, Laura J., additional, Gammon, Marilie D., additional, Chow, Wong-Ho, additional, Risch, Harvey A., additional, Corley, Douglas A., additional, Levine, David M., additional, Whiteman, David C., additional, Bernstein, Leslie, additional, Bird, Nigel C., additional, Vaughan, Thomas L., additional, and Wu, Anna H., additional

Published
2015
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9. Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma

Author

Ferguson, Heather R., primary, Wild, Christopher P., additional, Anderson, Lesley A., additional, Murphy, Seamus J., additional, Johnston, Brian T., additional, Murray, Liam J., additional, Watson, R.G. Peter, additional, McGuigan, Jim, additional, Reynolds, John V., additional, and Hardie, Laura J., additional

Published
2008
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10. No Association between hOGG1, XRCC1, and XPD Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, or Esophageal Adenocarcinoma: Results from the Factors Influencing the Barrett's Adenocarcinoma Relationship Case-Control Study.

Author

Ferguson, Heather R., Wild, Christopher P., Anderson, Lesley A., Murphy, Seamus J., Johnston, Brian T., Murray, Liam J., Watson, R. G. Peter, McGuigan, Jim, Reynolds, John V., and Hardie, Laura J.

Abstract

The article focuses on a study which examined the associations of the hOGG1 Ser326Cys, XRC1 Arg399Gln, and XPD Lys751 Gln polymorphisms with risk of esophageal carcinoma. The genotyping of the polymorphisms were made using TaqMan allelic discrimination assays. The characteristics of controls, reflux esophagitis, Barrett's esophagus and esophageal adenocarcinoma patients are given.

Published
2008
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11. Baseline Prostate-Specific Antigen Level and Risk of Prostate Cancer and Prostate-Specific Mortality: Diagnosis Is Dependent on the Intensity of Investigation.

Author

Connolly, David, Black, Amanda, Gavin, Anna, Keane, Patrick F., and Murray, Liam J.

Abstract

The article focuses on a study on the risk of prostate cancer in men due to the widespread use of prostate-specific antigen (PSA) testing in Northern Ireland. It discusses the results of the study which provide data to inform men who have a low baseline PSA of their risk of prostate cancer and prostate cancer-specific mortality if they do not undergo early investigation. It stresses the need for men to be aware of the harm cancer may cause them.

Published
2008
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12. Pleiotropic Analysis of Cancer Risk Loci on Esophageal Adenocarcinoma Risk.

Author

Eunjung Lee, Stram, Daniel O., Ek, Weronica E., Onstad, Lynn E., MacGregor, Stuart, Gharahkhani, Puya, Weimin Ye, Lagergren, Jesper, Shaheen, Nicholas J., Murray, Liam J., Hardie, Laura J., Gammon, Marilie D., Wong-Ho Chow, Risch, Harvey A., Corley, Douglas A., Levine, David M., Whiteman, David C., Bernstein, Leslie, Bird, Nigel C., and Vaughan, Thomas L.

Abstract

Background: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus. Methods: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn. Results: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed. Conclusions: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus. Impact: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks ofEAand Barrett's esophagus. [ABSTRACT FROM AUTHOR]

Published
2015
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