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Start Over Author "Weiss, Raymond A." Journal cancer chemotherapy and pharmacology
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9. Nephrotoxicity of lomustine

Author

Ellis, Mark E., Weiss, Raymond B., and Kuperminc, Mario

Abstract

A patient is presented who developed nephrotoxicity after therapy with lomustine (CCNU) for astrocytoma of the brain. Only three other cases of lomustine nephrotoxicity have been reported, and all cases have been associated with cumulative drug doses of greater than 1,500 mg/m2. The clinical and pathologic features of lomustine nephrotoxicity are reviewed. It is recommended that cumulative doses of more than 1,200–1,400 mg/m2 lomustine be avoided because of the risk of nephrotoxicity.

Published
1985
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