1. Pharmacokinetics and safety of cetuximab in a patient with renal dysfunction.
- Author
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Krens, L., Baas, J., Verboom, M., Paintaud, G., Desvignes, C., Guchelaar, H., and Gelderblom, H.
- Subjects
PHARMACOKINETICS ,MEDICATION safety ,CETUXIMAB ,KIDNEY diseases ,ANTINEOPLASTIC agents ,CANCER chemotherapy ,KIDNEY failure ,PATIENTS ,THERAPEUTICS - Abstract
Introduction: In the literature, data on the effect of renal impairment on the pharmacokinetics of anticancer drugs are scarce. Here, we report a 68-year-old metastatic osteosarcoma patient with impaired renal function due to prior chemotherapy, who was treated on compassionate use basis with 400 mg/m cetuximab. Material and methods: Pharmacokinetic parameters after the first dose, including dose-normalised AUC from time zero to day 7, clearance, elimination half-life ( t), were estimated using trapezoidal non-compartmental methods and compared to pharmacokinetic data from a study population with normal kidney function. Results: The results showed that the pharmacokinetics of cetuximab in this patient with renal failure was similar to that with adequate renal function. Conclusion: This study suggests that cetuximab can be safely used in cancer patients with renal impairment without dose adjustment. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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