1. mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
- Author
-
Souroullas GP and Sharpless NE
- Subjects
- AMP-Activated Protein Kinases, Animals, Humans, Mechanistic Target of Rapamycin Complex 1, Melanoma, Experimental pathology, Multiprotein Complexes metabolism, Nevus metabolism, Protein Serine-Threonine Kinases metabolism, Proto-Oncogene Proteins B-raf metabolism, Skin Neoplasms metabolism, TOR Serine-Threonine Kinases metabolism
- Abstract
Oncogene-induced senescence (OIS) is thought to be a barrier to malignant transformation resulting from the strong activation of oncogenes. In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF