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Your search keyword '"Santhanam Ramasamy"' showing total 9 results
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9 results on '"Santhanam Ramasamy"'

1. Retraction Notice to: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, primary, Suh, Sung-Suk, additional, Rocci, Alberto, additional, De Luca, Luciana, additional, Taccioli, Cristian, additional, Santhanam, Ramasamy, additional, Zhou, Wenchao, additional, Benson, Don M., additional, Hofmainster, Craig, additional, Alder, Hansjuerg, additional, Garofalo, Michela, additional, Di Leva, Gianpiero, additional, Volinia, Stefano, additional, Lin, Huey-Jen, additional, Perrotti, Danilo, additional, Kuehl, Michael, additional, Aqeilan, Rami I., additional, Palumbo, Antonio, additional, and Croce, Carlo M., additional

Published
2022
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2. Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation

Author

Mishra, Anjali, Liu, Shujun, Sams, Gregory H., Curphey, Douglas P., Santhanam, Ramasamy, Rush, Laura J., Schaefer, Deanna, Falkenberg, Lauren G., Sullivan, Laura, Jaroncyk, Laura, Yang, Xiaojuan, Fisk, Harold, Wu, Lai-Chu, Hickey, Christopher, Chandler, Jason C., Wu, Yue-Zhong, Heerema, Nyla A., Chan, Kenneth K., Perrotti, Danilo, Zhang, Jianying, Porcu, Pierluigi, Racke, Frederick K., Garzon, Ramiro, Lee, Robert J., Marcucci, Guido, and Caligiuri, Michael A.

Published
2012
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3. Sp1/NFκB/HDAC/ miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia

Author

Liu, Shujun, Wu, Lai-Chu, Pang, Jiuxia, Santhanam, Ramasamy, Schwind, Sebastian, Wu, Yue-Zhong, Hickey, Christopher J., Yu, Jianhua, Becker, Heiko, Maharry, Kati, Radmacher, Michael D., Li, Chenglong, Whitman, Susan P., Mishra, Anjali, Stauffer, Nicole, Eiring, Anna M., Briesewitz, Roger, Baiocchi, Robert A., Chan, Kenneth K., Paschka, Peter, Caligiuri, Michael A., Byrd, John C., Croce, Carlo M., Bloomfield, Clara D., Perrotti, Danilo, Garzon, Ramiro, and Marcucci, Guido

Published
2010
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4. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

Author

Neviani, Paolo, Santhanam, Ramasamy, Trotta, Rossana, Notari, Mario, Blaser, Bradley W., Liu, Shujun, Mao, Hsiaoyin, Chang, Ji Suk, Galietta, Annamaria, Uttam, Ashwin, Roy, Denis C., Valtieri, Mauro, Bruner-Klisovic, Rebecca, Caligiuri, Michael A., Bloomfield, Clara D., Marcucci, Guido, and Perrotti, Danilo

Published
2005
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5. RETRACTED: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, primary, Suh, Sung-Suk, additional, Rocci, Alberto, additional, De Luca, Luciana, additional, Taccioli, Cristian, additional, Santhanam, Ramasamy, additional, Zhou, Wenchao, additional, Benson, Don M., additional, Hofmainster, Craig, additional, Alder, Hansjuerg, additional, Garofalo, Michela, additional, Di Leva, Gianpiero, additional, Volinia, Stefano, additional, Lin, Huey-Jen, additional, Perrotti, Danilo, additional, Kuehl, Michael, additional, Aqeilan, Rami I., additional, Palumbo, Antonio, additional, and Croce, Carlo M., additional

Published
2016
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6. RETRACTED: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Jr., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, and Croce, Carlo M.

Published
2010
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7. Sp1/NFκB/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia

Author

Liu, Shujun, primary, Wu, Lai-Chu, additional, Pang, Jiuxia, additional, Santhanam, Ramasamy, additional, Schwind, Sebastian, additional, Wu, Yue-Zhong, additional, Hickey, Christopher J., additional, Yu, Jianhua, additional, Becker, Heiko, additional, Maharry, Kati, additional, Radmacher, Michael D., additional, Li, Chenglong, additional, Whitman, Susan P., additional, Mishra, Anjali, additional, Stauffer, Nicole, additional, Eiring, Anna M., additional, Briesewitz, Roger, additional, Baiocchi, Robert A., additional, Chan, Kenneth K., additional, Paschka, Peter, additional, Caligiuri, Michael A., additional, Byrd, John C., additional, Croce, Carlo M., additional, Bloomfield, Clara D., additional, Perrotti, Danilo, additional, Garzon, Ramiro, additional, and Marcucci, Guido, additional

Published
2010
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8. Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, and Croce, Carlo M.

Subjects
*GENETIC regulation, *NON-coding RNA, *MULTIPLE myeloma, *P53 antioncogene, *B cell lymphoma, *ENZYME inhibitors, *GENE expression, *GENE targeting, *GENETIC mutation
Abstract

Summary: In multiple myeloma (MM), an incurable B cell neoplasm, mutation or deletion of p53 is rarely detected at diagnosis. Using small-molecule inhibitors of MDM2, we provide evidence that miR-192, 194, and 215, which are downregulated in a subset of newly diagnosed MMs, can be transcriptionally activated by p53 and then modulate MDM2 expression. Furthermore, ectopic re-expression of these miRNAs in MM cells increases the therapeutic action of MDM2 inhibitors in vitro and in vivo by enhancing their p53-activating effects. In addition, miR-192 and 215 target the IGF pathway, preventing enhanced migration of plasma cells into bone marrow. The results suggest that these miRNAs are positive regulators of p53 and that their downregulation plays a key role in MM development. [ABSTRACT FROM AUTHOR]

Published
2010
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9. Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development.

Author

Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, and Croce, Carlo M.

Subjects
*DOWNREGULATION, *P53 antioncogene, *MICRORNA, *MULTIPLE myeloma, *PROTEIN kinase B
Published
2016
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