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7 results on '"Rocci, Alberto"'

1. Retraction Notice to: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, primary, Suh, Sung-Suk, additional, Rocci, Alberto, additional, De Luca, Luciana, additional, Taccioli, Cristian, additional, Santhanam, Ramasamy, additional, Zhou, Wenchao, additional, Benson, Don M., additional, Hofmainster, Craig, additional, Alder, Hansjuerg, additional, Garofalo, Michela, additional, Di Leva, Gianpiero, additional, Volinia, Stefano, additional, Lin, Huey-Jen, additional, Perrotti, Danilo, additional, Kuehl, Michael, additional, Aqeilan, Rami I., additional, Palumbo, Antonio, additional, and Croce, Carlo M., additional

Published
2022
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2. Cancer-selective targeting of the NF-?B survival pathway with GADD45ß/MKK7 inhibitors

Author

Tornatore Laura, Sandomenico Annamaria, Raimondo Domenico, Low Caroline, Rocci Alberto, Tralau-Stewart Cathy, Capece Daria, D'Andrea Daniel, Bua Marco, Boyle Eileen, van Duin Mark, Zoppoli Pietro, Jaxa-Chamiec Albert, Thotakura Anil K, Dyson Julian, Walker Brian A, Leonardi Antonio, Chambery Angela, Driessen Christoph, Sonneveld Pieter, Morgan Gareth, Palumbo Antonio, Tramontano Anna, Rahemtulla Amin, and Ruvo Menotti

Abstract

Constitutive NF ?B signaling promotes survival in multiple myeloma (MM) and other cancers; however current NF ?B targeting strategies lack cancer cell specificity. Here we identify the interaction between the NF ?B regulated antiapoptotic factor GADD45ß and the JNK kinase MKK7 as a therapeutic target in MM. Using a drug discovery strategy we developed DTP3 a D tripeptide which disrupts the GADD45ß/MKK7 complex kills MM cells effectively and importantly lacks toxicity to normal cells. DTP3 has similar anticancer potency to the clinical standard bortezomib but more than 100 fold higher cancer cell specificity in vitro. Notably DTP3 ablates myeloma xenografts in mice with no apparent side effects at the effective doses. Hence cancer selective targeting of the NF ?B pathway is possible and at least for myeloma patients promises a profound benefit.

Published
2014
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3. RETRACTED: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, primary, Suh, Sung-Suk, additional, Rocci, Alberto, additional, De Luca, Luciana, additional, Taccioli, Cristian, additional, Santhanam, Ramasamy, additional, Zhou, Wenchao, additional, Benson, Don M., additional, Hofmainster, Craig, additional, Alder, Hansjuerg, additional, Garofalo, Michela, additional, Di Leva, Gianpiero, additional, Volinia, Stefano, additional, Lin, Huey-Jen, additional, Perrotti, Danilo, additional, Kuehl, Michael, additional, Aqeilan, Rami I., additional, Palumbo, Antonio, additional, and Croce, Carlo M., additional

Published
2016
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4. Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Author

Tornatore, Laura, primary, Sandomenico, Annamaria, additional, Raimondo, Domenico, additional, Low, Caroline, additional, Rocci, Alberto, additional, Tralau-Stewart, Cathy, additional, Capece, Daria, additional, D’Andrea, Daniel, additional, Bua, Marco, additional, Boyle, Eileen, additional, van Duin, Mark, additional, Zoppoli, Pietro, additional, Jaxa-Chamiec, Albert, additional, Thotakura, Anil K., additional, Dyson, Julian, additional, Walker, Brian A., additional, Leonardi, Antonio, additional, Chambery, Angela, additional, Driessen, Christoph, additional, Sonneveld, Pieter, additional, Morgan, Gareth, additional, Palumbo, Antonio, additional, Tramontano, Anna, additional, Rahemtulla, Amin, additional, Ruvo, Menotti, additional, and Franzoso, Guido, additional

Published
2014
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5. RETRACTED: Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Jr., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, and Croce, Carlo M.

Published
2010
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6. Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

Author

Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, and Croce, Carlo M.

Subjects
*GENETIC regulation, *NON-coding RNA, *MULTIPLE myeloma, *P53 antioncogene, *B cell lymphoma, *ENZYME inhibitors, *GENE expression, *GENE targeting, *GENETIC mutation
Abstract

Summary: In multiple myeloma (MM), an incurable B cell neoplasm, mutation or deletion of p53 is rarely detected at diagnosis. Using small-molecule inhibitors of MDM2, we provide evidence that miR-192, 194, and 215, which are downregulated in a subset of newly diagnosed MMs, can be transcriptionally activated by p53 and then modulate MDM2 expression. Furthermore, ectopic re-expression of these miRNAs in MM cells increases the therapeutic action of MDM2 inhibitors in vitro and in vivo by enhancing their p53-activating effects. In addition, miR-192 and 215 target the IGF pathway, preventing enhanced migration of plasma cells into bone marrow. The results suggest that these miRNAs are positive regulators of p53 and that their downregulation plays a key role in MM development. [ABSTRACT FROM AUTHOR]

Published
2010
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7. Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development.

Author

Pichiorri, Flavia, Suh, Sung-Suk, Rocci, Alberto, De Luca, Luciana, Taccioli, Cristian, Santhanam, Ramasamy, Zhou, Wenchao, Benson, Don M., Hofmainster, Craig, Alder, Hansjuerg, Garofalo, Michela, Di Leva, Gianpiero, Volinia, Stefano, Lin, Huey-Jen, Perrotti, Danilo, Kuehl, Michael, Aqeilan, Rami I., Palumbo, Antonio, and Croce, Carlo M.

Subjects
*DOWNREGULATION, *P53 antioncogene, *MICRORNA, *MULTIPLE myeloma, *PROTEIN kinase B
Published
2016
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