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Your search keyword '"Cho, Hee-Jin"' showing total 4 results
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4 results on '"Cho, Hee-Jin"'

1. Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

Author

Jeon, Hye-Min, Kim, Jeong-Yub, Cho, Hee Jin, Lee, Won Jun, Nguyen, Dayna, Kim, Sung Soo, Oh, Young Taek, Kim, Hee-Jin, Jung, Chan-Woong, Pinero, Gonzalo, Joshi, Tanvi, Hambardzumyan, Dolores, Sakaguchi, Takuya, Hubert, Christopher G., McIntyre, Thomas M., Fine, Howard A., Gladson, Candece L., Wang, Bingcheng, Purow, Benjamin W., Park, Jong Bae, Park, Myung Jin, Nam, Do-Hyun, and Lee, Jeongwu

Published
2023
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2. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Author

Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C, Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Sauvé, Charles-Etienne Gabriel, Olar, Adriana, Lan, Zheng D, Finocchiaro, Gaetano, Phillips, Joanna J, Berger, Mitchel S, Gabrusiewicz, Konrad R, Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A, Muller, Florian, Heimberger, Amy B, Sulman, Erik P, Nam, Do-Hyun, and Verhaak, Roel GW

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Genetics, Brain Cancer, Neurosciences, Brain Disorders, Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Phenotype, Recurrence, Survival Analysis, T-Lymphocytes, Tumor Microenvironment, disease recurrence, glioblastoma, immune cells, macrophages/microglia, mesenchymal subtype, proneural to mesenchymal transition, tumor evolution, tumor microenvironment, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microenvironment. In silico cell sorting identified macrophages/microglia, CD4+ T lymphocytes, and neutrophils in the glioma microenvironment. NF1 deficiency resulted in increased tumor-associated macrophages/microglia infiltration. Longitudinal transcriptome analysis showed that expression subtype is retained in 55% of cases. Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence. Hypermutation at diagnosis or at recurrence associated with CD8+ T cell enrichment. Frequency of M2 macrophages detection associated with short-term relapse after radiation therapy.

Published
2017

3. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Author

Wang, Qianghu, primary, Hu, Baoli, additional, Hu, Xin, additional, Kim, Hoon, additional, Squatrito, Massimo, additional, Scarpace, Lisa, additional, deCarvalho, Ana C., additional, Lyu, Sali, additional, Li, Pengping, additional, Li, Yan, additional, Barthel, Floris, additional, Cho, Hee Jin, additional, Lin, Yu-Hsi, additional, Satani, Nikunj, additional, Martinez-Ledesma, Emmanuel, additional, Zheng, Siyuan, additional, Chang, Edward, additional, Gabriel Sauvé, Charles-Etienne, additional, Olar, Adriana, additional, Lan, Zheng D., additional, Finocchiaro, Gaetano, additional, Phillips, Joanna J., additional, Berger, Mitchel S., additional, Gabrusiewicz, Konrad R., additional, Wang, Guocan, additional, Eskilsson, Eskil, additional, Hu, Jian, additional, Mikkelsen, Tom, additional, DePinho, Ronald A., additional, Muller, Florian, additional, Heimberger, Amy B., additional, Sulman, Erik P., additional, Nam, Do-Hyun, additional, and Verhaak, Roel G.W., additional

Published
2018
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4. Spatiotemporal Evolution of the Primary Glioblastoma Genome

Author

Kim, Jinkuk, primary, Lee, In-Hee, additional, Cho, Hee Jin, additional, Park, Chul-Kee, additional, Jung, Yang-Soon, additional, Kim, Yanghee, additional, Nam, So Hee, additional, Kim, Byung Sup, additional, Johnson, Mark D., additional, Kong, Doo-Sik, additional, Seol, Ho Jun, additional, Lee, Jung-Il, additional, Joo, Kyeung Min, additional, Yoon, Yeup, additional, Park, Woong-Yang, additional, Lee, Jeongwu, additional, Park, Peter J., additional, and Nam, Do-Hyun, additional

Published
2015
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