1. Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors
- Author
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Jaime M. Guidry Auvil, Vicki Huff, Yussanne Ma, Richard A. Moore, Julie M. Gastier-Foster, Denise Brooks, Jeffrey S. Dome, Daniela S. Gerhard, Jing Ma, Yueh-Yun Chi, Marco A. Marra, Jacqueline E. Schein, Malcolm A. Smith, Oliver A. Hampton, Elizabeth J. Perlman, Ariadne H. A. G. Ooms, Andrew J. Mungall, Amy L. Walz, Nicole Ross, Qing-Rong Chen, Reanne Bowlby, Chih Hao Hsu, Chunhua Yan, Daoud Meerzaman, Charles G. Mullighan, David A. Wheeler, Samantha Gadd, Nadereh Jafari, Cu Nguyen, Ying Hu, and Pathology
- Subjects
Ribonuclease III ,Cancer Research ,DGCR8 ,Mesenchyme ,Loss of Heterozygosity ,Nerve Tissue Proteins ,Bioinformatics ,Polymorphism, Single Nucleotide ,Wilms Tumor ,Article ,Loss of heterozygosity ,Perilobar nephrogenic rest ,microRNA ,medicine ,Humans ,Drosha ,Homeodomain Proteins ,biology ,RNA-Binding Proteins ,Histology ,Wilms' tumor ,Cell Biology ,medicine.disease ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,medicine.anatomical_structure ,Oncology ,Favorable histology ,Cancer cell ,Mutation ,biology.protein ,Cancer research ,Homeobox ,Neoplasm Recurrence, Local - Abstract
SummaryWe report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors). Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberrations. Significantly decreased expression of mature Let-7a and the miR-200 family (responsible for mesenchymal-to-epithelial transition) in miRNAPG mutant tumors is associated with an undifferentiated blastemal histology. The combination of SIX and miRNAPG mutations in the same tumor is associated with evidence of RAS activation and a higher rate of relapse and death.
- Published
- 2015
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