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Your search keyword '"Martin, Richard M"' showing total 35 results
Start Over Author "Martin, Richard M" Journal cancer causes & control
35 results on '"Martin, Richard M"'

10. The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium

Author

PRACTICAL consortium, Davies, Neil M., Gaunt, Tom R., Lewis, Sarah J., Holly, Jeff, Donovan, Jenny L., Hamdy, Freddie C., Kemp, John P., Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Olama, Ali Amin Al, Benlloch, Sara, Muir, Kenneth, Giles, Graham G., Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A., Schleutker, Johanna, Nordestgaard, Børge G., Travis, Ruth C., Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L., Blot, William J., Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S., Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R., Pandha, Hardev, Lathrop, Mark, Smith, George Davey, and Martin, Richard M.

Published
2015

27. Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study

Author

Gilbert, Rebecca, primary, Bonilla, Carolina, additional, Metcalfe, Chris, additional, Lewis, Sarah, additional, Evans, David M., additional, Fraser, William D., additional, Kemp, John P., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Neal, David E., additional, Lane, J. Athene, additional, Smith, George Davey, additional, Lathrop, Mark, additional, and Martin, Richard M., additional

Published
2014
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30. Insulin-like growth factors (IGFs) and IGF-binding proteins in active monitoring of localized prostate cancer: a population-based observational study

Author

Rowlands, Mari-Anne, primary, Tilling, Kate, additional, Holly, Jeff M. P., additional, Metcalfe, Chris, additional, Gunnell, David, additional, Lane, Athene, additional, Davis, Michael, additional, Donovan, Jenny, additional, Hamdy, Freddie, additional, Neal, David E., additional, and Martin, Richard M., additional

Published
2012
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34. The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium

Author

Davies, Neil M, Gaunt, Tom R, Lewis, Sarah J, Holly, Jeffrey M P, Donovan, Jenny L, Hamdy, Freddie C, Kemp, John P, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Pandha, Hardev, Lathrop, Mark, Davey Smith, George, and Martin, Richard M

Subjects
Male, Cancer Research, Genotype, Polymorphism, Single Nucleotide, White People, Body Mass Index, Risk Factors, Mendelian randomization, Humans, Obesity, Body mass index, Alleles, Adiposity, Aged, Original Paper, Prostate cancer, Height, Incidence, Genetic Variation, Prostatic Neoplasms, Single nucleotide polymorphisms, Mendelian Randomization Analysis, Middle Aged, Body Height, Phenotype, Oncology, Case-Control Studies, Instrumental variables analysis, ICEP
Abstract

Background Epidemiological studies suggest a potential role for obesity and determinants of adult stature in prostate cancer risk and mortality, but the relationships described in the literature are complex. To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality. Methods We conducted a case–control study based on 20,848 prostate cancers and 20,214 controls of European ancestry from 22 studies in the PRACTICAL consortium. We constructed genetic risk scores that summed each man’s number of height and BMI increasing alleles across multiple single nucleotide polymorphisms robustly associated with each phenotype from published genome-wide association studies. Results The genetic risk scores explained 6.31 and 1.46 % of the variability in height and BMI, respectively. There was only weak evidence that genetic variants previously associated with increased BMI were associated with a lower prostate cancer risk (odds ratio per standard deviation increase in BMI genetic score 0.98; 95 % CI 0.96, 1.00; p = 0.07). Genetic variants associated with increased height were not associated with prostate cancer incidence (OR 0.99; 95 % CI 0.97, 1.01; p = 0.23), but were associated with an increase (OR 1.13; 95 % CI 1.08, 1.20) in prostate cancer mortality among low-grade disease (p heterogeneity, low vs. high grade p heterogeneity = 0.03). Conclusions We found little evidence of a substantial effect of genetically elevated height or BMI on prostate cancer risk, suggesting that previously reported observational associations may reflect common environmental determinants of height or BMI and prostate cancer risk. Genetically elevated height and BMI were associated with increased mortality (prostate cancer-specific and all-cause, respectively) in men with low-grade disease, a potentially informative but novel finding that requires replication.

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35. Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study

Author

Gilbert, Rebecca, Bonilla, Carolina, Metcalfe, Chris, Lewis, Sarah, Evans, David M., Fraser, William D., Kemp, John P., Donovan, Jenny L., Hamdy, Freddie C., Neal, David E., Lane, J. Athene, Smith, George Davey, Lathrop, Mark, and Martin, Richard M.

Subjects
Male, Risk, Cancer Research, Epidemiology, 25 hydroxyvitamin-D, Polymorphism, Single Nucleotide, Risk Assessment, Calcitriol, Risk Factors, Biomarkers, Tumor, Odds Ratio, Humans, Vitamin D, Vitamin D3 24-Hydroxylase, Vitamin D pathway genes, Alleles, Aged, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Original Paper, Prostate cancer, Vitamin D-Binding Protein, Prostatic Neoplasms, Middle Aged, Prostate-Specific Antigen, 1,25-dihydroxyvitamin-D, 1117 Public Health And Health Services, Oncology, Centre for Surgical Research, Case-Control Studies, Gene-Environment Interaction, 1112 Oncology And Carcinogenesis
Abstract

Purpose Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer. Methods In a nested case–control study (within the ProtecT trial), we estimated odds ratios and 95 % confidence intervals (CIs) quantifying associations between SNPs and prostate cancer. Subgroup analyses investigated whether associations were stronger in men who had high/low sun exposure [a proxy for 25(OH)D]. We quantified associations of SNPs with stage (T1–T2/T3–T4) and grade (

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