1. Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium
- Author
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Voltzke, Kristin J, Lee, Yuan-Chin Amy, Zhang, Zuo-Feng, Zevallos, Jose P, Yu, Guo-Pei, Winn, Deborah M, Vaughan, Thomas L, Sturgis, Erich M, Smith, Elaine, Schwartz, Stephen M, Schantz, Stimson, Muscat, Joshua, Morgenstern, Hal, McClean, Michael, Li, Guojun, Lazarus, Philip, Kelsey, Karl, Gillison, Maura, Chen, Chu, Boffetta, Paolo, Hashibe, Mia, and Olshan, Andrew F
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Tobacco Smoke and Health ,Rare Diseases ,Dental/Oral and Craniofacial Disease ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Prevention ,Cancer ,Clinical Research ,Tobacco ,Good Health and Well Being ,Alcohol Drinking ,Case-Control Studies ,Head and Neck Neoplasms ,Humans ,Racial Groups ,Risk Factors ,Tobacco Use ,United States ,Head and neck cancer ,Alcohol ,Cigarette smoking ,African American ,Racial difference ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology and carcinogenesis - Abstract
There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous studies have been limited by small numbers of Blacks. Using pooled data from 13 US case-control studies of oral, pharyngeal, and laryngeal cancers in the International Head and Neck Cancer Epidemiology Consortium, this study comprised a large number of Black HNC cases (n = 975). Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for several tobacco and alcohol consumption characteristics. Blacks were found to have consistently stronger associations than Whites for the majority of tobacco consumption variables. For example, compared to never smokers, Blacks who smoked cigarettes for > 30 years had an OR 4.53 (95% CI 3.22-6.39), which was larger than that observed in Whites (OR 3.01, 95% CI 2.73-3.33; pinteraction
- Published
- 2018