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Your search keyword '"K Kenne"' showing total 2 results
Start Over Author "K Kenne" Journal cancer biochemistry biophysics
2 results on '"K Kenne"'

1. Deoxyribonucleoside triphosphate pool levels in three cell strains of human chromosome instability syndromes: ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368)

Author

K, Kenne and L, Akerblom

Subjects
Ataxia Telangiectasia, Fanconi Anemia, Deoxyribonucleotides, Mutation, Anemia, Aplastic, Humans, Fibroblasts, Bloom Syndrome, Cell Division, Cell Line, Culture Media, Thymidine
Abstract

Deoxyribonucleoside triphosphate (dNTP) pool sizes were determined in cell strains derived from patients with the genetic diseases ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368), and were compared to the dNTP pools in a normal human fibroblast cell strain (253/79). In addition, the effect of deoxythymidine on both dNTP pool levels and cell growth was examined. The three mutant cell strains differed only slightly from the normal cell strain. The cellular characteristics of the cell strains, such as chromosome instability, are apparently not an effect of dNTP pool imbalance.

Published
1990

2. Deoxyribonucleoside triphosphate pool levels in three cell strains of human chromosome instability syndromes: ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368).

Author

Kenne K and Akerblom L

Subjects
Cell Division drug effects, Cell Line, Culture Media, Fibroblasts metabolism, Humans, Mutation, Thymidine metabolism, Anemia, Aplastic metabolism, Ataxia Telangiectasia metabolism, Bloom Syndrome metabolism, Deoxyribonucleotides metabolism, Fanconi Anemia metabolism
Abstract

Deoxyribonucleoside triphosphate (dNTP) pool sizes were determined in cell strains derived from patients with the genetic diseases ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368), and were compared to the dNTP pools in a normal human fibroblast cell strain (253/79). In addition, the effect of deoxythymidine on both dNTP pool levels and cell growth was examined. The three mutant cell strains differed only slightly from the normal cell strain. The cellular characteristics of the cell strains, such as chromosome instability, are apparently not an effect of dNTP pool imbalance.

Published
1990

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