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24 results on '"Symmans, W. Fraser"'

1. Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer

Author

Shinde, Shivani S., Forman, Michele R., Kuerer, Henry M., Yan, Kai, Peintinger, Florentia, Hunt, Kelly K., Hortobagyi, Gabriel N., Pusztai, Lajos, and Symmans, W. Fraser

Subjects
Breast cancer -- Risk factors, Breast cancer -- Development and progression, Breast cancer -- Demographic aspects, Breast cancer -- Research, Breast feeding -- Research, Parity (Obstetrics) -- Research, Health
Published
2010

2. Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival

Author

Williams, Stephanie A., Ehlers, Richard A. II, Hunt, Kelly K., Yi, Min, Kuerer, Henry M., Singletary, S. Eva, Ross, Merrick I., Feig, Barry W., Symmans, W. Fraser, and Meric-Bernstam, Funda

Subjects
Metastasis -- Research, Metastasis -- Patient outcomes, Metastasis -- Physiological aspects, Breast cancer -- Care and treatment, Breast cancer -- Research, Breast cancer -- Patient outcomes, Breast cancer -- Development and progression, Mastectomy -- Patient outcomes, Mastectomy -- Research, Breast -- Biopsy, Breast -- Research, Health
Published
2007

3. The safety of breast-conserving surgery in patients who achieve a complete pathologic response after neoadjuvant chemotherapy

Author

Peintinger, Florentia, Symmans, W. Fraser, Gonzalez-Angulo, Ana M., Boughey, Judy C., Buzdar, Aman U., Yu, T. Kuan, Hunt, Kelly K., Singletary, S. Eva, Babiera, Gildy V., Lucci, Anthony, Meric-Bernstam, Funda, and Kuerer, Henry M.

Subjects
Mastectomy -- Research, Chemotherapy -- Patient outcomes, Chemotherapy -- Complications and side effects, Chemotherapy -- Research, Dose-response relationship (Biochemistry) -- Research, Health
Published
2006

4. Impact of concurrent proliferative high-risk lesions on the risk of ipsilateral breast carcinoma recurrence and contralateral breast carcinoma development in patients with ductal carcinoma in situ treated with breast conserving therapy

Author

Adepoju, Linda J., Symmans, W. Fraser, Babiera, Gildy V., Singletary, S. Eva, Arun, Banu, Sneige, Nour, Pusztai, Lajos, Buccholz, Thomas A., Sahin, Aysegul, Hunt, Kelly K., Meric-Bernstam, Funda, Ross, Merrick I., Ames, Frederick C., and Kuerer, Henry M.

Subjects
Breast cancer -- Risk factors, Carcinoma in situ -- Complications and side effects, Mastectomy -- Research, Tamoxifen -- Research, Cancer -- Relapse, Cancer -- Risk factors, Health
Published
2006

5. Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma

Author

Pusztai, Ljos, Gregory, Betsy W., Baggerly, Keith A., Peng, Bo, Koomen, John, Kuerer, henry M., Esteva, Francisco J., Symmans, W. Fraser, Wagner, Peter, Hortobagyi, Gabriel N., Laronga, Christine, Semmes, O. John, Wright, George L., Drake, Richard R., and Vlahou, Antonia

Subjects
Chemotherapy -- Risk factors, Chemotherapy -- Research, Breast cancer -- Diagnosis, Breast cancer -- Research, Cancer -- Chemotherapy, Cancer -- Risk factors, Cancer -- Research, Cancer -- Diagnosis, Health
Published
2004

6. Change in tumor cellularity of breast carcinoma after neodjuvant chemotherapy as a variable in the pathologic assessment of response

Author

Rajan, Radhika, Poniecka, Anna, Smith, Terry L., Yang, Ying, Frye, Deborah, Pusztai, Lajos, Fiterman, Derek J., Gal-Gombos, Eva, Whitman, Gary, Rouzier, Roman, Green, Marjorie, Kuerer, Henry, Buzdar, Aman U., Hortobagyi, Gabriel N., and Symmans, W. Fraser

Subjects
Chemotherapy -- Patient outcomes, Chemotherapy -- Case studies, Chemotherapy -- Methods, Chemotherapy -- Evaluation, Breast cancer -- Patient outcomes, Breast cancer -- Care and treatment, Breast cancer -- Case studies, Cancer -- Chemotherapy, Cancer -- Patient outcomes, Cancer -- Case studies, Cancer -- Methods, Cancer -- Evaluation, Health
Published
2004

7. Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

Author

Hao, Xishan, Sun, Baocun, Hu, Limei, Lahdesmaki, Harri, Dunmire, Valerie, Feng, Yumei, Zhang, Shi-Wu, Wang, Huamin, Wu, Chunlei, Wang, Hua, Fuller, Gregory N., Symmans, W. Fraser, Shmulevich, Ilya, and Zhang, Wei

Subjects
Gene expression -- Observations, Lymphatic metastasis -- Care and treatment, DNA microarrays -- Comparative analysis, DNA microarrays -- Observations, Breast cancer -- Prognosis, Health
Published
2004

8. Total RNA yield and microarray gene expression profiles from fine-needle asperation biopsy and core-needle biopsy samples of breast carcinoma

Author

Symmans, W. Fraser, Ayers, Mark, Clark, Edwin A., Stec, James, Hess, Kenneth R., Sneige, Nour, Buchholz, Thomas A., Krishnamurthy, Savitri, Ibrahim, Nuhad K., Buzdar, Aman U., Theriault, Richard L., Rosales, Marguerite F.M., Thomas, Eva S., Gwyn, Karin M., Green, Marjorie C., Syed, Abdul R., Hortobagyi, Gabriel N., and Pusztai, Lajos

Subjects
DNA microarrays -- Research, Breast cancer -- Research, Biopsy, Needle -- Analysis, Health
Published
2003

9. Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma

Author

Fan Zhang, Ying Yang, Smith, Terry, Shu-Wan Kau, McConathy, Judy M., Esteva, Francisco J., Kuerer, Henry M., Symmans, W. Fraser, Buzdar, Aman U., Hortobagyi, Gabriel N., and Pusztai, Lajos

Subjects
Breast cancer -- Patient outcomes, Breast cancer -- Drug therapy, Breast cancer -- Genetic aspects, Gene expression -- Physiological aspects, Chemotherapy -- Physiological aspects, Chemotherapy -- Patient outcomes, Health
Published
2003

15. Correlation between HER‐2 expression and response to neoadjuvant chemotherapy with 5‐fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma

Author

Zhang, Fan, primary, Yang, Ying, additional, Smith, Terry, additional, Kau, Shu‐Wan, additional, McConathy, Judy M., additional, Esteva, Francisco J., additional, Kuerer, Henry M., additional, Symmans, W. Fraser, additional, Buzdar, Aman U., additional, Hortobagyi, Gabriel N., additional, and Pusztai, Lajos, additional

Published
2003
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23. Local, regional, and systemic recurrence rates in patients undergoing skin-sparing mastectomy compared with conventional mastectomy.

Author

Yi M, Kronowitz SJ, Meric-Bernstam F, Feig BW, Symmans WF, Lucci A, Ross MI, Babiera GV, Kuerer HM, and Hunt KK

Subjects
Adult, Aged, Aged, 80 and over, Breast Neoplasms epidemiology, Breast Neoplasms pathology, Carcinoma, Ductal, Breast epidemiology, Carcinoma, Ductal, Breast pathology, Databases, Factual, Disease-Free Survival, Female, Humans, Incidence, Mastectomy, Segmental statistics & numerical data, Mastectomy, Simple statistics & numerical data, Middle Aged, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local pathology, Recurrence, Retrospective Studies, Young Adult, Breast Neoplasms surgery, Carcinoma, Ductal, Breast surgery, Dermatologic Surgical Procedures, Mastectomy, Segmental methods, Mastectomy, Simple methods, Neoplasm Recurrence, Local epidemiology
Abstract

Background: Although the use of SSM is becoming more common, there are few data on long-term, local-regional, and distant recurrence rates after treatment. The purpose of this study was to examine the rates of local, regional, and systemic recurrence, and survival in breast cancer patients who underwent skin-sparing mastectomy (SSM) or conventional mastectomy (CM) at our institution., Methods: Patients with stage 0 to III unilateral breast cancer who underwent total mastectomy at our center from 2000 to 2005 were included in this study. Kaplan-Meier curves were calculated, and the log-rank test was used to evaluate the differences between overall and disease-free survival rates in the 2 groups., Results: Of 1810 patients, 799 (44.1%) underwent SSM and 1011 (55.9%) underwent CM. Patients who underwent CM were older (58.3 vs 49.3 years, P<.0001) and were more likely to have stage IIB or III disease (53.0% vs 31.8%, P<.0001). Significantly more patients in the CM group received neoadjuvant chemotherapy and adjuvant radiation therapy (P<.0001). At a median follow-up of 53 months, 119 patients (6.6%) had local, regional, or systemic recurrences. The local, regional, and systemic recurrence rates did not differ significantly between the SSM and CM groups. After adjusting for clinical TNM stage and age, disease-free survival rates between the SSM and CM groups did not differ significantly., Conclusions: SSM is an acceptable treatment option for patients who are candidates for immediate breast reconstruction. Local-regional recurrence rates are similar to those of patients undergoing CM. Cancer 2011. © 2010 American Cancer Society., (Copyright © 2010 American Cancer Society.)

Published
2011
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24. Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytologic specimens of breast carcinoma.

Author

Gong Y, Symmans WF, Krishnamurthy S, Patel S, and Sneige N

Subjects
Adult, Aged, Aged, 80 and over, Biopsy, Needle, Female, Humans, Immunohistochemistry, Middle Aged, Neoplasm Staging, Probability, Sampling Studies, Sensitivity and Specificity, Specimen Handling, Adenocarcinoma pathology, Breast Neoplasms pathology, Receptors, Estrogen isolation & purification, Tissue Fixation methods
Abstract

Background: The techniques for immunostaining estrogen receptor (ER) in cytologic specimens have varied, as have the detection rates. The authors compared various fixation methods for their effect on ER detection in cytologic smears of breast carcinoma., Methods: Smears were prepared by gently scraping the cut surfaces of 47 resected breast carcinoma specimens and placing immediately in 1 of the following conditions: 1) a sequence of 10% formalin-methanol-acetone fixatives at -20 degrees C (Abbott method); 2) 10% formalin at room temperature; and 3) Carnoy's fixative at room temperature and then Papanicolaou stained (Carnoy's-Pap). Destaining of Carnoy's-Pap smears (Carnoy's-dPap) was initially attempted before ER staining. One set of smears was also air-dried for 3 minutes before using the Abbott method. Smears and corresponding tissue sections were immunostained with anti-ER antibody 6F11 using a similar protocol except for antigen retrieval, which was not initially applied on cytologic slides. All the ER-negative smears that had been fixed with 10% formalin or Carnoy's-Pap were restained after antigen retrieval. Agreement between cytologic and histologic findings was expressed by both concordance and the kappa coefficient., Results: ER detection in smears processed with the Abbott method correlated best with findings from tissue samples, with an overall correlation of 91.5% (kappa = 0.80). Findings from air-dried smears were less optimal (concordance, 84.4%; kappa = 0.65), followed by Carnoy's-Pap (concordance, 71.4%; kappa = 0.45), formalin (concordance, 31%; kappa = 0.05), and Carnoy's-dPap (concordance, 29.4%; kappa = 0.04). Antigen retrieval converted most of the ER-negative smears to positive (18 of 20 smears in formalin and 6 of 8 smears in Carnoy's-Pap), leading to a final concordance of 93% and kappa = 0.83 for both conditions. Antigen retrieval also led to stronger staining intensity without causing false positivity., Conclusions: Antigen retrieval was found to greatly improve ER immunodetectability and staining intensity in formalin-fixed and Carnoy's-Pap smears. The former may offer an alternative to the Abbott method because of its easiness and the latter can be reliably used in archival Pap-stained smears for retrospective analysis of ER. Air-drying, destaining Pap smear, and fixation in formalin or Carnoy's-Pap without antigen retrieval are not recommended., (Copyright 2003 American Cancer Society.)

Published
2004
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