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Sinus histiocytosis with massive lymphadenopathy is a benign disorder often characterized by spontaneous remission. Although immunologic abnormalities are common and high Epstein Barr virus titers have been reported, to date no case has been associated with malignant lymphoma. The authors report here the first case of this association.

A 42-year-old male presented with adenocarcinoma of the palate and nephrotic syndrome. Renal biopsy demonstrated membranous glomerulopathy in which carcinoembryonic antigen was demonstrated. Carcinoembryonic antigen was also found in the palatal tumor. This is the first instance of this association with this particular tumor.