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This paper reports the preliminary results of a controlled study randomizing MOPP vs. a new four-drug combination (ABVD) in advanced Hodgkin's disease. ABVD consists of 6 cycles of adriamycin, bleomycin, vinblastine, and imidazole carboxamide. The purpose for designing this new combination was two-fold: to compare the efficacy of ABVD with MOPP, and to demonstrate absence of cross-resistance between the two regimens. Of 60 patients entered into the study, 45 (MOPP25, ABVD20) are presently evaluable for the analysis of remission induction. No patient was previously treated with chemotherapy; 20% had relapsed after primary radiotherapy. Whenever possible, complete remission was defined also through rebiopsy of known organ involvement. Complete remission occurred in 76% of patients treated with MOPP and in 75% of those given ABVD, with no difference between the two regimens as far as stage (IIIB-IIIS and IV), histologic type, and prior irradiation were concerned. Crossover carried out for progressive disease or for relapse after initial remission showed absence of cross-resistance between MOPP and ABVD. Toxic manifestations after ABVD were in general well tolerated and reversible. The percent of optimal dose for each drug was as follows: adriamycin 87%, vinblastine 87%, bleomycin 96%, and imidazole carboxamide 96%. These preliminary results indicate that in terms of complete remission, ABVD could represent a successful alternative to MOPP to be used either in MOPP failures or in sequential combination with MOPP. However, the lack of long-term followup limits at the present time an adequate comparison between the two treatments.

This paper is a review of 120 cases of primary malignant melanoma of the oral cavity occurring in the Japanese. We have collected 18 cases from our own department and the remainder from the literature. Since malignant melanoma arising from the oral mucosa and ectopic pigmentation are relatively common in Japan, an assumption has grown as to a possible relationship to histogenesis. The analysis of the material and the discussion are focused on these points. Malignant melanoma of the oral cavity is not rare in the Japanese. Some of the cases do not seem to have any relation to oral melanosis, but almost two-thirds of the cases were found associated with it (36.2% of melanoma was associated with pre-existing melanosis, and 29.8% with concurrent or later-developing melanosis). The biological behavior and histologic patterns of these melanoses were similar to those of lentigo maligna of the skin. The pre-existing melanoses seemed to be the most common precancerous lesion of the oral mucosa as far as malignant melanoma was concerned.

The progressive improvement in the prognosis of acute lymphocytic leukemia has been a result of two major developments: 1) the more efficient use of chemotherapeutic agents, particularly the use of combinations of agents and the discovery that agents effective at one stage of disease may be inappropriate at another stage, and 2) the prevention with irradiation of central nervous system relapse. As many as one-half of children with this disease may enjoy long-term leukemia-free survival. However, further studies are needed to improve the efficacy and reduce the toxicity of therapy. This paper reviews the evolution of some of these studies.

The present study deals with 11 malignant tumors arising from the spermatic cord. Ten of the tumors were of mesoblastic origin and one was a teratoma. Local recurrence appeared to be a common problem and was attributed to inadequate removal of the primary tumor at biopsy. Distant metastasis occurred only in the late stages of disease after local recurrence could not be controlled or when retroperitoneal disease had become extensive. Radical orchiectomy followed by retroperitoneal node dissection was considered the treatment of choice for this disease. ETWEEN THE YEARS 1931 AND 1966, 24 PAB tients with tumors of the testicular adnexa were seen at the Memorial and James Ewing Hospitals. Of these, 13 arose in the spermatic cord, 7 in the epididymis, 2 from the tunica albuginea and 1 each from the rete testis and an adrenal rest, respectively. Of particular interest were those cases which were histologically malignant, since many of these had presented with primary intrascrotal swellings often confused with testicular tumor. In addition, these tumors constituted an uncommon group of neoplasms for which the clinical course and prognosis had not been clearly defined.l.11, 21, 34 The present paper deals specifically with the spermatic cord tumors considered to be histologically malignant. Experience with the other adnexal lesions will be described sep

This paper records the frequency and the types of all 46 verified tumors of the minor salivary glands seen during a 8-year period at the University departments of Pathology and Oral Histopathology, Umea, Sweden. The series consisted of 39 benign mixed tumors, 1 oxyphil adenoma, 2 malignant mixed tumors, 3 mucoepidermoid carcinomas and 1 adenoid cystic carcinoma. This series was compared with other series regarding classification and pathologic anatomy. Attention has been called especially to differences in the reported incidences of malignant tumors: in the present series the incidence was unusually low. It is proposed that the nature of the hospitals where most of the published materials were collected could explain the divergencies between different series, which thus seem to represent biased samples. This implies that the widely accepted belief that an unusually high percentage of malignant tumors is found in the minor salivary glands must be seriously questioned.