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A 4-year-old Huacaya hembra was evaluated for acute neurologic signs including recumbency and a left head tilt. Cranial nerve examination revealed a left ear droop, muzzle deviation to the right, mydriasis of the left eye, an absent menace response, bilateral absent pupillary light reflex when light was directed into the left eye, and bilateral horizontal nystagmus with fast phase to the right. Multifocal intracranial lesions were suspected. Computed tomography revealed an intracranial mass. Postmortem examination, histopathology, and sequencing of a polymerase chain reaction product confirmed a diagnosis of phaeohyphomycotic meningoencephalitis caused by Cladophialophora bantiana . Key clinical message: Advanced diagnostic imaging (computed tomography) was useful in achieving a diagnosis of an intracranial mass in an alpaca with acute neurological signs, later confirmed to be central nervous system (CNS) phaeohyphomycosis. Although uncommon, intracranial fungal infection should be considered as a differential diagnosis in camelid patients exhibiting CNS signs, particularly if they do not respond to initial antimicrobial and anthelmintic therapy., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)