1. Effect of preoperative long-term opioid therapy on patient outcomes after total knee arthroplasty: an analysis of multicentre population-based administrative data
- Author
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Goplen, C. Michael, Kang, Sung Hyun, Randell, Jason R., Jones, C. Allyson, Voaklander, Donald C., Churchill, Thomas A., and Beaupre, Lauren A.
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Opioids -- Patient outcomes ,Knee pain -- Drug therapy -- Patient outcomes ,Preoperative care -- Patient outcomes ,Health ,Health care industry - Abstract
Background: Up to 40% of patients are receiving opioids at the time of total knee arthroplasty (TKA) in the United States despite evidence suggesting opioids are ineffective for pain associated with arthritis and have substantial risks. Our primary objective was to determine whether preoperative opioid users had worse knee pain and physical function outcomes 12 months after TKA than patients who were opioidnaive preoperatively; our secondary objective was to determine the prevalence of opioid use before and after TKA in Alberta, Canada. Methods: In this retrospective analysis of population-based data, we identified adult patients who underwent TKA between 2013 and 2015 in Alberta. We used multivariable linear regression to examine the association between preoperative opioid use and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical function scores 12 months after TKA, adjusting for potentially confounding variables. Results: Of the 1907 patients, 592 (31.0%) had at least 1 opioid dispensed before TKA, and 124 (6.5%) were classified as long-term opioid users. Long-term opioid users had worse adjusted WOMAC pain and physical function scores 12 months after TKA than patients who were opioid-naive preoperatively (pain score (3 = 7.7, 95% confidence interval [CI] 4.0 to 11.6; physical function score (3 = 7.8, 95% CI 4.0 to 11.6; p < 0.001 for both). The majority (89 ([71.8%]) of patients who were long-term opioid users preoperatively were dispensed opioids 180-360 days after TKA, compared to 158 (12.0%) patients who were opioid-naive preoperatively. Conclusion: A substantial number of patients were dispensed opioids before and after TKA, and patients who received opioids preoperatively had worse adjusted pain and functional outcome scores 12 months after TKA than patients who were opioidnaive preoperatively. These results suggest that patients prescribed opioids preoperatively should be counselled judiciously regarding expected outcomes after TKA. Contexte : Jusqu'a 40 % des patients se font prescrire des opioides lors d'une chirurgie pour prothese totale du genou (PTG) aux Etats-Unis, et ce, malgre des donnees selon lesquelles les opioides sont inefficaces pour la douleur associee a l'arthrite et comportent des risques substantiels. Notre objectif principal etait de determiner si les patients qui utilisaient deja des opioides en periode preoperatoire obtenaient des resultats plus negatifs aux plans de la douleur et du fonctionnement 12 mois apres leur PTG, comparativement aux patients qui ne prenaient pas d'opioides avant leur intervention; notre objectif secondaire etait de mesurer la prevalence du recours aux opioides avant et apres la PTG en Alberta, au Canada. Methodes : Dans cette analyse retrospective menee sur des donnees de population, nous avons identifie les patients adultes soumis a une PTG entre 2013 et 2015 en Alberta. Nous avons utilise un modele de regression lineaire multivarie pour examiner le lien entre l'utilisation d'opioides en periode preoperatoire et les scores de douleur et de fonctionnement a l'echelle WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) 12 mois apres la PTG, en tenant compte de potentielles variables de confusion. Resultats : Sur les 1907 patients, 592 (31,0 %) ont recu au moins 1 opioide avant leur PTG, et 124 (6,5 %) en etaient consideres des utilisateurs de longue date. Les utilisateurs d'opioides de longue date presentaient de moins bons scores WOMAC ajustes pour les domaines de douleur et de fonctionnement 12 mois apres la PTG, comparativement aux patients qui n'en prenaient pas avant l'intervention (score de douleur (3 = 7,7, intervalle de confiance [IC] de 95 % 4,0 a 11,6; score de fonctionnement (3 = 7,8, IC de 95 % 4,0 a 11,6; p < 0,001 pour les 2 domaines). La majorite (89 [71,8 %]) des patients utilisateurs d'opioides de longue date avant l'intervention se sont fait servir des opioides 180-360 jours apres la PTG, comparativement a 158 patients (12,0 %) qui n'en prenaient pas avant l'intervention. Conclusion : Un nombre substantiel de patients ont recu des opioides avant et apres la PTG, et ceux qui en prenaient avant l'intervention presentaient des scores de douleur et de fonctionnement ajustes plus defavorables 12 mois apres la PTG, comparativement aux patients qui n'en prenaient pas avant l'intervention. Selon ces resultats, il faut adresser des conseils judicieux aux patients qui sont deja sous opioides en periode preoperatoire et les informer des resultats possibles de la PTG., Over the past 20 years, the number of opioids prescribed to manage arthritis has increased dramatically in North America despite emerging evidence suggesting that opioids provide no benefit compared to [...]
- Published
- 2021
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