1. The role of aspirin and inflammation on reproduction: the EAGeR trial
- Author
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Lindsay D. Levine, Lindsey A. Sjaarda, Keewan Kim, Tiffany L. Holland, Enrique F. Schisterman, and Sunni L. Mumford
- Subjects
0301 basic medicine ,Infertility ,Physiology ,Offspring ,Article ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Physiology (medical) ,medicine ,Animals ,Humans ,Pharmacology ,Inflammation ,Aspirin ,030219 obstetrics & reproductive medicine ,business.industry ,Reproduction ,Pregnancy Outcome ,General Medicine ,medicine.disease ,030104 developmental biology ,Relative risk ,Biomarker (medicine) ,Gestation ,Female ,Live birth ,business ,medicine.drug - Abstract
Inflammation has been linked to several complications in pregnancy, including pregnancy loss. Due to its anti-inflammatory properties, aspirin, a widely available and inexpensive therapy, has potential to help mitigate the negative effects of inflammation along the reproductive pathway. Therefore, the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was designed to elucidate whether preconception-initiated daily low-dose aspirin would increase the live birth rate in women with 1–2 prior pregnancy losses and no infertility diagnosis and attempting unassisted conception. Here, we present an overview of the collected findings. Low-dose aspirin was associated with an increased live birth rate among women with a single loss at
- Published
- 2018