1. Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation.
- Author
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Bernardes N, Ayyappan P, De Angelis K, Bagchi A, Akolkar G, da Silva Dias D, Belló-Klein A, and Singal PK
- Subjects
- Animals, Blood Pressure, Healthy Lifestyle, Humans, Hypertension blood, Hypertension etiology, Hypertension physiopathology, Hyperuricemia blood, Hyperuricemia etiology, Hyperuricemia metabolism, Inflammation blood, Inflammation physiopathology, Inflammation therapy, Inflammation Mediators blood, Metabolic Syndrome blood, Metabolic Syndrome physiopathology, Metabolic Syndrome therapy, Prognosis, Risk Factors, Risk Reduction Behavior, Uric Acid blood, Dietary Sugars adverse effects, Fructose adverse effects, Inflammation etiology, Metabolic Syndrome etiology, Oxidative Stress
- Abstract
A rapid rise in obesity, as well as physical inactivity, in industrialized countries is associated with fructose-consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension, and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress, and elevated levels of uric acid are also part of this syndrome. Lifestyle changes through improved physical activity, as well as nutrition, are important approaches to minimize metabolic syndrome and its deleterious effects.
- Published
- 2017
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