1. PTP1B and TC-PTP: novel roles in immune-cell signaling.
- Author
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Simoncic, Paul D., McGlade, C. Jane, and Tremblay, Michel L.
- Subjects
- *
CELLULAR signal transduction , *CELLS , *T cells , *HEMATOPOIESIS , *IMMUNE response - Abstract
It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators of the immune response. This review will focus on the substrate specificities of PTP1B and TC-PTP and their roles in immune cell signaling, and will discuss some new data implicating PTP1B and TC-PTP in myeloid development. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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