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Start Over Author "Anu Bala" Journal canadian journal of microbiology
2 results on '"Anu Bala"'

1. Synergy of a virulent phage (φAB182) with antibiotics leading to successful elimination of biofilms formed by MDR Acinetobacter baumannii

Author

Medhavi Vashisth, Shikha Yashveer, Anu Bala Jaglan, Nitin Virmani, Bidhan Chand Bera, Rajesh Kumar Vaid, and Taruna Anand

Subjects
Immunology, Genetics, General Medicine, Molecular Biology, Applied Microbiology and Biotechnology, Microbiology
Abstract

Emergence of multiple drug resistant (MDR) strains of Acinetobacter baumannii and a withering drug discovery pipeline necessitates the search for effective alternatives to replace or synergize with currently used antibiotics. In this report, we have described the synergy assessment of a virulent Acinetobacter baumannii phage φAB182 with a wide range of antibiotics. Myophage φAB182 was isolated from sewage against MDR A. baumannii and exhibited maximum stability at 25 °C and pH 7. It also had a short latent period of 9 min with a large burst size of 287. The phylogenetic analysis of its major capsid protein gene indicated an 84.15% similarity to the lytic A. baumannii phage Acj9. In the presence of antibiotics, phage φAB182 showed the highest synergy ( p combination/MBECantibiotic values (

Published
2022

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