Canadian society faces a significant decline in the number of active mines and in the discovery rate of base and precious metal deposits. Exploring in the shadows of active and former mines with improved metallogenic models and new technologies is one way to address this problem. Another way is to diversify mineral exploration outside known mining camps and target prospective but underexplored settings and nonconventional mineral deposits. In Canadian terms, diversifying exploration commonly translates into targeting gneissic and granitic terrains where modern geoscience knowledge may be rare or only at reconnaissance scale and where key regional and local indicators and vectors to ore may be missing in the geological record. Though underexplored settings abound in Canada, only one orogen has an aura that discourages exploration: the Grenville Province. Consequently, even though the Grenville Province provides the best model of a deep continental-collision zone so far studied anywhere on Earth and constitutes a microcosm of continental accretion, it remains underexplored, underprospected, undermapped and underestimated. It is thus essential to revisit the mineral potential of the most accessible orogen of the Canadian Shield, search for its missing volcanic belts, reexamine its ore deposits and mineral occurrences, and explore new research avenues using the best remote-sensing device on Earth: human eyes. This special issue captures advances associated with regional field investigations by government that played a special role in opening up frontier areas for mineral exploration. Papers stemming from academia and government–university–industry consortiums investigate further some of the topics covered by these and earlier surveys and others contribute structural and metamorphic insights that will be valuable in future mapping projects. The advances reported here for the Grenville Province may provide impetus to revisit other Grenville-age terrains worldwide, just as metallogenic models developed in other countries have provided the means to look in a different manner at the Grenville orogen for mineral deposits. Collectively all the various approaches presented in this volume help us to revamp our way of looking at the mineral potential of the Grenville orogen. [ABSTRACT FROM AUTHOR]