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A simple and sensitive sensor has been developed for the electrochemical determination of ciprofloxacin (CF). The proposed sensor was designed by chitosan-coated Fe3O4 magnetic nanoparticle incorporated in the carbon paste electrode (CPE), which provides remarkably improved sensitivity for the electrochemical determination of CF. The proposed sensor was characterized with scanning electron microscopy and electrochemical impedance spectroscopy. Under optimum conditions, the sensor provides two linear differential pulse voltammetry responses in the range of 0.05-6 μmol/L and 6-75 μmol/L for CF with a detection limit of 0.01 μmol/L. The proposed sensor exhibited high sensitivity and good selectivity and was successfully applied for CF determination in serum and urine samples. [ABSTRACT FROM AUTHOR]