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1. Comparison of serum creatinine levels in different color/race categories in a Brazilian population

Author

Roberto Carlos de Brito Barcellos, Jorge Paulo Strogoff de Matos, Hye Chung Kang, Maria Luiza Garcia Rosa, and Jocemir Ronaldo Lugon

Subjects
Creatinina, Tasa de Filtración Glomerular, Origen Étnico y Salud, Medicine, Public aspects of medicine, RA1-1270
Abstract

Serum creatinine (sCr) is usually higher among black people in the United States due to increased muscle mass, justifying the addition of race adjustment in creatinine-based formulas to estimate glomerular filtration rate (eGFR). We aimed to assess if sCr levels are different in low-income communities in Brazil according to their race. A total of 1,303 participants were enrolled (58% females, 50±14 years-old, 33% self-defined as white, 41% as mixed race, and 26% as black). No significant differences in sCr were found between racial groups and no influence of race on sCr was seen in the linear regression analysis. The eGFR, calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula with no race adjustment, was no different between whites, mixed race and blacks. However, using such adjustment, eGFR for mixed race and black individuals was significantly higher than for whites (p < 0.001). In conclusion, no significant differences in sCr levels were found between racial groups, raising doubts as to whether race adjustment in eGFR formula should be used in that population.

Published
2015
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2. Comparison of serum creatinine levels in different color/race categories in a Brazilian population

Author

Hye Chung Kang, Maria Luiza Garcia Rosa, Roberto Carlos de Brito Barcellos, Jorge Paulo Strogoff de Matos, and Jocemir Ronaldo Lugon

Subjects
Adult, Male, Origen Étnico y Salud, lcsh:Public aspects of medicine, lcsh:R, Public Health, Environmental and Occupational Health, Black People, lcsh:Medicine, Tasa de Filtración Glomerular, lcsh:RA1-1270, Middle Aged, behavioral disciplines and activities, White People, Cross-Sectional Studies, Sex Factors, Creatinine, Humans, Female, Creatinina, Brazil, Glomerular Filtration Rate
Abstract

Serum creatinine (sCr) is usually higher among black people in the United States due to increased muscle mass, justifying the addition of race adjustment in creatinine-based formulas to estimate glomerular filtration rate (eGFR). We aimed to assess if sCr levels are different in low-income communities in Brazil according to their race. A total of 1,303 participants were enrolled (58% females, 50±14 years-old, 33% self-defined as white, 41% as mixed race, and 26% as black). No significant differences in sCr were found between racial groups and no influence of race on sCr was seen in the linear regression analysis. The eGFR, calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula with no race adjustment, was no different between whites, mixed race and blacks. However, using such adjustment, eGFR for mixed race and black individuals was significantly higher than for whites (p < 0.001). In conclusion, no significant differences in sCr levels were found between racial groups, raising doubts as to whether race adjustment in eGFR formula should be used in that population.

Published
2015

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