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Post-burn pruritus is one of the most common complaints reported by patients with limited evidence for a gold-standard treatment. To review the literature and assess the efficacy of various interventions in treating post-burn pruritus. PubMed, MEDLINE, CINAHL, Web of Sciences, Ovid Databases, and ClinicalTrials.Gov were searched. The articles were scored by two assessors for inclusion with a third independent assessor resolving conflicting scores. The present systematic review and meta-analysis synthesised findings from a total of nine studies, representing a pool of 323 patients. The standardized mean effect size for the various categories of interventions was: naltrexone at 1.47 (95 % CI of 0.75–2.20, p < 0.0000), coverings at 0.94 (95 % CI of 0.40–1.48, p = 0.006), topical ozonated oil at 2.64 (95 % CI of 1.94–3.34, p < 0.00001), lasers at 2.34 (95 % CI of 1.60–3.09, p < 0.00001), current stimulation at 1.03 (95 % CI of −0.04 to 2.10, p = 0.06), and lemon balm tea at 0.54 (95% CI of 0.12–0.96, p = 0.01). Current evidence suggests that current modalities have a statistically significant, but not clinically significant, reduction in pruritus. This review highlights the limited quality of evidence in the literature and the poor quality of reporting among excluded studies. • Post-burn pruritus affects up to 93 % of patients with burn injuries by day of discharge. • Current treatment modalities do not achieve clinically significant reduction of symptoms. • Future studies in post-burn pruritus are warranted in both quantity and quality of data reporting. [ABSTRACT FROM AUTHOR]