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Moderate hypothermia stimulates LPO processes in rat plasma and erythrocytes and simultaneously increases antioxidant activity in the plasma and SOD activity erythrocyte. Dalargin prevents stimulation of LPO in the blood in hypothermia by reducing the generation of active oxygen species and maintaining the level of low-molecular antioxidants.

Short-term and prolonged (3 h) moderate (30°C) hypothermia intensified oxidative modification of plasma proteins, while deep hypothermia (20°C) decreased the intensity of this process to a control level. Preliminary intraperitoneal injection of dalargin had practically no effect on oxidative modification of plasma proteins during moderate hypothermia.

The change of ascorbic acid content was studied in adrenal glands and blood of rabbits during the development of artificial hypothermia; changes occurring in the weight of adrenal glands were recorded as well. A reduction of ascorbic acid content in the adrenal glands takes place in conditions of moderate hypothermia at temperatures ranging from 31 to 26°C; there was also a moderate increase in the weight of the glands and a rise of ascorbic acid content in the blood. With intensification of hypothermia at temperatures ranging from 26 to 25°C a marked drop of ascorbic acid content in adrenal glands is accompanied by a reduction of their weight and discharge of ascorbic acid into the blood. In deep hypothermia (25–23°C) the amount of ascorbic acid in adrenal glands rises, their weight increases, while the blood ascorbic acid content declines.