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Start Over Author "Zyuz'kova, Yu." Journal bulletin of experimental biology and medicine
4 results on '"Zyuz'kova, Yu."'

4. Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells.

Author

Zyuz'kov GN, Udut EV, Miroshnichenko LA, Polyakova TY, Simanina EV, Stavrova LA, Chaikovskii AV, Agafonov VI, Borodulina EV, Timofeev MS, Zyuz'kova YN, Danilets MG, Zhdanov VV, and Udut VV

Subjects
Animals, Anthraquinones pharmacology, Bone Marrow Cells cytology, Bone Marrow Cells drug effects, Cell Differentiation drug effects, Cell Proliferation drug effects, Fibroblasts cytology, Fibroblasts drug effects, Gene Expression Regulation, Janus Kinase 1 antagonists & inhibitors, Janus Kinase 1 metabolism, Janus Kinase 3 antagonists & inhibitors, Janus Kinase 3 metabolism, Mesenchymal Stem Cells cytology, Mesenchymal Stem Cells drug effects, Mice, Mice, Inbred C57BL, Nitriles, Phosphorylation, Primary Cell Culture, Pyrazoles pharmacology, Pyrimidines, STAT3 Transcription Factor antagonists & inhibitors, STAT3 Transcription Factor metabolism, Signal Transduction, Sulfonamides pharmacology, Bone Marrow Cells metabolism, Fibroblasts metabolism, Janus Kinase 1 genetics, Janus Kinase 3 genetics, Mesenchymal Stem Cells metabolism, STAT3 Transcription Factor genetics
Abstract

The role of JAK/STAT3-mediated signaling pathway in the realization of the growth potential of mesenchymal precursor cells was examined in vitro. The stimulating role of JAKs and STAT3 towards proliferating activity of progenitor cells and their different role in the regulation of differentiation of the progenitor elements were demonstrated. Inhibitors of JAKs and STAT3 reduced the yield of fibroblast CFU and their mitotic activity. Blockade of JAKs accelerated and selective inactivation of STAT3 decelerated differentiation of progenitor cells.

Published
2018
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