1. Specific Effects of Chondroitin Sulfate-Modified Hyaluronidase on the Function of Progenitor Cells
- Author
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V. V. Zhdanov, A. V. Chaikovskii, A. D. Turashev, A. A. Bekarev, P. G. Madonov, E. V. Simanina, L. A. Miroshnichenko, M. Yu. Minakova, E. V. Udut, G. N. Zyuz’kov, V. V. Udut, A. V. Artamonov, A.V. Maksimenko, and A. M. Dygai
- Subjects
Male ,Hyaluronoglucosaminidase ,Bone Marrow Cells ,Cell Count ,Stimulation ,Biology ,Regenerative Medicine ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Hyaluronidase ,Precursor cell ,Cell Adhesion ,medicine ,Animals ,Chondroitin sulfate ,Progenitor cell ,Fibroblast ,Stem Cells ,Chondroitin Sulfates ,Mesenchymal stem cell ,General Medicine ,Cell biology ,medicine.anatomical_structure ,chemistry ,Biochemistry ,Mice, Inbred CBA ,Female ,Stem cell ,medicine.drug - Abstract
We have demonstrated the possibility of stimulation of the function of various types of precursor cells with hyaluronidase modified with chondroitin sulfate. Parenteral administration of modified hyaluronidase increased the number of fibroblast, granulomonocyte, and erythroid CFU in the hemopoietic tissue. The changes in the pool of mesenchymal progenitor cells were more pronounced in comparison with those induced by native enzyme.
- Published
- 2014
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