Search

Your search keyword '"A. G. Mazhuga"' showing total 3 results
Start Over Author "A. G. Mazhuga" Journal bulletin of experimental biology and medicine
3 results on '"A. G. Mazhuga"'

1. Contrast Agents Based on Iron Oxide Nanoparticles for Clinical Magnetic Resonance Imaging

Author

S K Ternovoi, A G Pistrak, A. G. Mazhuga, Maxim A. Abakumov, B Ya Myshkinis, M. V. Konstantinov, Vladimir P. Chekhonin, D M Dmitriev, and E. I. Demikhov

Subjects
0301 basic medicine, Materials science, media_common.quotation_subject, Iron oxide, Contrast Media, Ferric Compounds, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nuclear magnetic resonance, Cell Line, Tumor, medicine, Animals, Contrast (vision), Magnetite Nanoparticles, media_common, medicine.diagnostic_test, Brain, Magnetic resonance imaging, General Medicine, Rat brain, medicine.disease, Magnetic Resonance Imaging, eye diseases, Rats, 030104 developmental biology, chemistry, Magnetic nanoparticles, Glioblastoma, human activities, 030217 neurology & neurosurgery, Iron oxide nanoparticles
Abstract

Magnetic resonance imaging (MRI) is one of the most perspective methods of noninvasive visualization in medicine, and use of contrast agents significantly its potentialities extends. Iron oxide nanoparticles are promising contrast agents, but in fact all the data on their efficiency were obtained in high-field tomographs for experimental animals. We studied the possibility of using magnetic nanoparticles for MRI visualization of rat brain glioblastoma at the most common clinical field 1.5 T The data indicate the efficiency of iron oxide magnetic nanoparticles as contrast agents for 1.5 T MR tomographs.

Published
2019
Full Text
View/download PDF

2. Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing

Author

Alexander G. Savchenko, Nikolai V. Zyk, O. A. Zhironkina, Elena K. Beloglazkina, Alexey E. Machulkin, A. G. Mazhuga, Anastasiia S Garanina, and V. E. Kotelyanskii

Subjects
Male, 0301 basic medicine, Oncology, Cytoplasm, medicine.medical_specialty, Contrast Media, Nanoparticle, Nanoconjugates, urologic and male genital diseases, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Prostate cancer, Cell Line, Tumor, Internal medicine, LNCaP, medicine, Glutamate carboxypeptidase II, Humans, Magnetite Nanoparticles, Chemistry, Prostatic Neoplasms, General Medicine, Ligand (biochemistry), medicine.disease, In vitro, 030104 developmental biology, Colloidal gold, Cancer research, Gold, Conjugate
Abstract

We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA-) and LNCaP (PSMA+) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.

Published
2016
Full Text
View/download PDF

3. Visualization and Cytotoxicity of Fluorescence-Labeled Dimeric Magnetite-Gold Nanoparticles Conjugated with Prostate-Specific Membrane Antigen in Mouse Macrophages

Author

Georgy V. Maksimov, V. B. Turovetskii, Anna B. Druzhko, Pirutin Sk, A. G. Mazhuga, M. V. Efremova, and Alexander Yusipovich

Subjects
0301 basic medicine, Glutamate Carboxypeptidase II, Male, Primary Cell Culture, Nanoparticle, Contrast Media, Conjugated system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Line, Tumor, Glutamate carboxypeptidase II, Animals, Humans, Cytotoxicity, Magnetite Nanoparticles, Fluorescent Dyes, Cell Death, Chemistry, Prostate, General Medicine, Carbocyanines, Fluorescence, Endocytosis, 030104 developmental biology, Membrane, Colloidal gold, Cytoplasm, Antigens, Surface, Biophysics, Macrophages, Peritoneal, Gold, 030217 neurology & neurosurgery, Protein Binding
Abstract

We demonstrated the possibility of penetration of magnetite-gold nanoparticles conjugated with prostate-specific membrane antigen into mouse macrophages. It was found that after 3-h incubation with nanoparticles in a concentration of 15 mg/liter at 37oC, they were seen in only 13% macrophages. In about 90% cells, the nanoparticles were detected within the cytoplasm. Under these conditions, membrane damage was revealed in 25% cells. These results should be taken into account in further development and application of nanomaterials for diagnostic and therapeutic purposes in oncology.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results