1. Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells.
- Author
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Yarygin KN, Suzdal'tseva YG, Burunova VV, Voronov AV, Petrakova NV, Cheglakov IB, Stupin VA, and Yarygin VN
- Subjects
- AC133 Antigen, Animals, Antigens analysis, Antigens, CD analysis, Antigens, CD34 analysis, Biomarkers analysis, Female, Fibroblasts transplantation, Glycoproteins analysis, Humans, Immunohistochemistry, Intermediate Filament Proteins analysis, Nerve Tissue Proteins analysis, Nestin, Peptides analysis, Rats, Rats, Wistar, Vimentin analysis, von Willebrand Factor immunology, Collagen Type I analysis, Collagen Type II analysis, Fibroblasts chemistry, HLA-A1 Antigen analysis, Skin cytology, Umbilical Cord cytology
- Abstract
Expression of markers, collagens, and HLA-1 by human skin fibroblasts and fibroblast-like cells isolated from the umbilical Wharton's jelly was compared. Skin fibroblasts express collagens (proteins characteristic of differentiated cells of this histogenetic series) and HLA-1, while umbilical cells express, in addition to collagens, juvenile surface markers and almost no HLA-1. This indicates that fibroblast-like cells isolated from different sources are different and can serve as sources for the creation of cell preparations with different characteristics in future.
- Published
- 2006
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