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Careless Herbicidal aerial spray of a field for weed control and defoliation of cotton before machine picking, resulted in the contamination of an adjoining reservoir, killing large volume of fish. The dead catfish, along with water and Amarantha weed leaves analyzed contained relatively high levels of arsenic concentrations, indicative of arsenic being the probable cause of fish killing. The arsenic absorbed by fish was irreversable and its bioaccumulation continued in the surviving fish though the water arsenic level fell during the following weeks.