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Start Over Author "B. Leclerq" Journal bulletin du cancer
2 results on '"B. Leclerq"'

1. Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity

Author

M, Ghosn, P, Carde, B, Leclerq, F, Flamant, S, Friedman, J P, Droz, and M, Hayat

Subjects
Brain Diseases, Epilepsy, Adolescent, Phenobarbital, Humans, Drug Interactions, Drug Therapy, Combination, Female, Ifosfamide, Mercaptoethanol, Mesna
Abstract

A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.

Published
1988

2. Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.

Author

Ghosn M, Carde P, Leclerq B, Flamant F, Friedman S, Droz JP, and Hayat M

Subjects
Adolescent, Drug Interactions, Drug Therapy, Combination, Epilepsy drug therapy, Female, Humans, Phenobarbital metabolism, Phenobarbital therapeutic use, Brain Diseases chemically induced, Ifosfamide adverse effects, Mercaptoethanol analogs & derivatives, Mesna adverse effects
Abstract

A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.

Published
1988

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