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According to EIA, the Heating Ventilation and Air Conditioning (HAVC) systems account for about 25% of the U.S.’s total commercial building’s energy use. Therefore, advanced modeling and optimization methods of the system components and operation offer great ways to reduce energy consumption in all types of buildings and mainly commercial buildings. This research introduced an innovative integrated two-level optimization technique for the HVAC system to reduce the total energy consumption while improving the indoor thermal comfort level. The process uses actual system performance data collected for the building automation systems (BAS) to create accurate component modeling and optimization process as the first level of optimization (MLO). Artificial neural networks were chosen to be the tool used to serve the process of modeling. The second optimization level utilizes the whole system-level optimization technique (SLO) using a genetic algorithm (G.A.). The proposed two-levels optimization technique will optimize the system setpoints, the supply air temperature, duct static pressure, minimum zone air flowrates, and minimum outdoor air ventilation rate. The proposed technique has contributed to the field of modeling and optimization of HVAC systems through several new contributions. (1) Implementing the demand control methodology with the optimization process to modify the electricity consumption power profile when the demand signal is received. (2) Implement the occupancy schedule inputs into the optimization process to adjust the ventilation airflow rates accordingly. (3) Implement the real-time zone occupancy sensor readings and adjust the zone’s ventilation flowrates and minimum flowrates. (4) Lastly, implementing the method of zone minimum air flowrates setpoint rests to reduce reheat requirements. The proposed optimization process was tested and validated, resulting in savings in the total energy consumed by the chilled water VAV system by 13.4%, 22.4 %, followed by 31% for July, February, and October, respectively.

Most of the energy consumed by the residential and commercial buildings in the U.S. is dedicated to space cooling and heating systems, according to the U.S. Energy Information Administration. Therefore, the need for better operation mechanisms of those existing systems become more crucial. The most vital factor for that is the need for accurate models that can accurately predict the system component performance. Therefore, this paper’s primary goal is to develop a new accurate data-driven modeling and optimization technique that can accurately predict the performance of the selected system components. Several data-enabled modeling techniques such as artificial neural networks (ANN), support vector machine (SVM), and aggregated bootstrapping (BSA) are investigated, and model improvements through model structure optimization proposed. The optimization algorithm will determine the optimal model structures and automate the process of the parametric study. The optimization problem is solved using a genetic algorithm (GA) to reduce the error between the simulated and actual data for the testing period. The models predicted the performance of the chilled water variable air volume (VAV) system’s main components of cooling coil and fan power as a function of multiple inputs. Additionally, the packaged DX system compressor modeled, and the compressor power was predicted. The testing results held a low coefficient of variation (CV%) values of 1.22% for the cooling coil, and for the fan model, it was found to be 9.04%. The testing results showed that the proposed modeling and optimization technique could accurately predict the system components’ performance.