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Haemoglobin synthesis was studied in fetal blood samples obtained at 17 to 20 weeks' gestation in 22 women at risk of carrying a fetus with homozygous -thalassaemia. A presumptive diagnosis of homozygous -thalassaemia was made in four cases, and the pregnancy was terminated. An inconclusive answer was obtained in one case, and the patient also chose to have her pregnancy terminated. Two fetuses were lost as a result of the procedure. Of the remaining 15 pregnancies, 13 proceeded to term and, two to 36 weeks; in: each case a normal infant or one heterozygous for -thalassaemia was delivered.
Current efforts should be directed towards improving the blood sampling technology so that fetal blood sampling can be used widely technology so that fetal blood thalassaemia is a major problem. [ABSTRACT FROM AUTHOR]

Studies the effect of introducing antenatal diagnosis on reproductive behavior of families at risk for thalassemia major in Great Britain. Prevention of severe congenital disease; Administration of iron-chelating agent desferrioxamine; Termination of pregnancy.

Reports developments related to medicine in Great Britain. Arguments on the abolition of community health councils; Measurement of plasma level of paracetamol; Importance of antenatal assessment for fetal and maternal health.

Examines impact of technological advances on fetal medicine in Great Britain. Importance of antenatal care on reducing mortality; Effectivity of labor induction on pregnant women; Assessment on efficiency of antenatal cardiotocography on giving information on condition of fetus.

Investigates the prenatal diagnosis of hemoglobinopathies in Great Britain. Prevalence of sickle-cell anemia and thalassemia; Chemical analysis of the emoglobin of fetuses; Need for further blood sampling techniques for diagnosis.

Discusses the difficulties in providing prenatal diagnostic service in Great Britain. Facilities for prenatal diagnosis; Importance of prenatal diagnosis; Cost-effectiveness of alpha fetoprotein.