Search

Your search keyword '"Brophy M"' showing total 2 results
Start Over Author "Brophy M" Journal british journal of surgery
2 results on '"Brophy M"'

1. Rapamycin is associated with platelet activation and increased spleen size: a mechanism for rapamycin-induced thrombocytopenia?

Author

Hayes, N. J., Nicholson, M. L., Jones, C., Brophy, M., Goodall, A. H., and Hayes, P. D.

Subjects
RAPAMYCIN, IMMUNOSUPPRESSIVE agents, MACROLIDE antibiotics, BLOOD platelet activation, SPLEEN, LYMPHOID tissue
Abstract

Studies the effect of rapamycin on platelets in vivo and in vitro. Utilization of flow cytometry; Increase of in vitro resting platelet degranulation; Effect of splenic sequestration of activated platelets.

Published
2004

2. Calcineurin channel inhibitors stimulate platelet degranulation and fibrogen binding in a dose-dependent manner.

Author

Hayes, N. J., Hayes, P. D., Brophy, M., Jones, C., Goodall, A. H., and Nicholson, M. L.

Subjects
CHEMICAL inhibitors, BLOOD platelets, FIBRINOGEN, CYCLOSPORINE, TACROLIMUS, KIDNEY diseases
Abstract

Presents a study on the capability of calcineurin channel inhibitors to stimulate platelet degranulation and fibrinogen binding in a dose-dependent manner. Evaluation of the impact of various dosages of cyclosporin A and tacrolimus; Determination of the expression of P-selectin; Involvement of the inhibitors in the pathogenesis of chronic allograft nephropathy.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results