Background: Between-match recovery time, and acute and chronic workloads likely affect subsequent match-injury risk in elite rugby league players., Methods: Workloads of 28 players throughout two seasons were calculated during short (<7 days), and long (≥7 days) between-match recovery times. 'Acute' workloads (1 week) greater than 'chronic' workloads (4-week rolling average acute workload) resulted in acute:chronic workload ratios above 1., Results: No difference was found between the match-injury risk of short and long between-match recovery periods (7.5±2.5% vs 6.8±2.5%). When players had a short recovery between matches, high chronic workloads (18.9-22.0 km) were associated with a smaller risk of match injury than chronic workloads <18.9 km (relative risk (RR) range 0.27-0.32 (CI 0.08 to 0.92); likelihood range 90-95%, likely). Players who had shorter recovery and acute:chronic workload ratios ≥1.6, were 3.4-5.8 times likely to sustain a match injury than players with lower acute:chronic workload ratios (RR range 3.41-5.80 (CI 1.17 to 19.2); likelihood range 96-99%, very likely). Acute:chronic workload ratios between 1.2 and 1.6 during short between-match recovery times demonstrated a greater risk of match injury than ratios between 1.0 and 1.2 (RR=2.88 (CI 0.97 to 8.55); likelihood=92%, likely)., Conclusions: Contrary to the philosophy that high workloads and shorter recovery equate to increased injury risk, our data suggest that high and very-high chronic workloads may protect against match injury following shorter between-match recovery periods. Acute:chronic workload ratios ∼1.5 are associated with a greater risk of match injury than lower acute:chonic workload ratios. Importantly, workloads can be manipulated to decrease the match-injury risk associated with shorter recovery time between matches., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)