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The COVID‐19 pandemic has impacted the world in many ways; for example, evidence from the United Kingdom indicates that higher rates of discriminatory behaviours against immigrants have been recorded during this period. Prior research suggests that political orientation and trust are instrumental in discriminatory beliefs against immigrants. A longitudinal study (six waves and a follow‐up) was conducted in the United Kingdom during the COVID‐19 pandemic (September 2020–August 2021) using convenience sampling (N = 383). The hypotheses enquired about whether political orientation predicts trust in government, trust in science and discriminatory beliefs. Multilevel regression and mediation analyses were conducted, using repeated measures nested within individuals. It was found that conservative views are associated with higher discriminatory beliefs, lower trust in science and higher trust in government. Furthermore, trust in science promotes reduction of discrimination, whereas trust in government, increases discriminatory beliefs. However, a nuance revealed by an interaction effect, shows that a positive alignment between political and scientific authorities may be required to reduce prejudice against immigrants. Exploratory multilevel mediation showed that trust is a mediator between political orientation and discriminatory beliefs. [ABSTRACT FROM AUTHOR]