1. Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome.
- Author
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Bonnin CM, Torrent C, Arango C, Amann BL, Solé B, González-Pinto A, Crespo JM, Tabarés-Seisdedos R, Reinares M, Ayuso-Mateos JL, García-Portilla MP, Ibañez Á, Salamero M, Vieta E, and Martinez-Aran A
- Subjects
- Adult, Bipolar Disorder drug therapy, Cognitive Behavioral Therapy, Executive Function, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Single-Blind Method, Spain, Treatment Outcome, Bipolar Disorder therapy
- Abstract
Background: Few randomised clinical trials have examined the efficacy of an intervention aimed at improving psychosocial functioning in bipolar disorder., Aims: To examine changes in psychosocial functioning in a group that has been enrolled in a functional remediation programme 1 year after baseline., Method: This was a multicentre, randomised, rater-masked clinical trial comparing three patient groups: functional remediation, psychoeducation and treatment as usual over 1-year follow-up. The primary outcome was change in psychosocial functioning measured by means of the Functioning Assessment Short Test (FAST). Group×time effects for overall psychosocial functioning were examined using repeated-measures ANOVA (trial registration NCT01370668)., Results: There was a significant group×time interaction for overall psychosocial functioning, favouring patients in the functional remediation group (F = 3.071, d.f. = 2, P = 0.049)., Conclusions: Improvement in psychosocial functioning is maintained after 1-year follow-up in patients with bipolar disorder receiving functional remediation., (© The Royal College of Psychiatrists 2016.)
- Published
- 2016
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