1. Hyperbaric oxygen increases plasma exudation in rat trachea: involvement of nitric oxide
- Author
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M Bernareggi, Enzo Chiesara, Giuseppe Rossoni, Ferruccio Berti, G Oriani, and Sonia Radice
- Subjects
Pharmacology ,Hyperoxia ,chemistry.chemical_classification ,medicine.medical_specialty ,Reactive oxygen species ,biology ,Chemistry ,Vascular permeability ,Nitric oxide ,Nitric oxide synthase ,chemistry.chemical_compound ,Endocrinology ,Anesthesia ,Internal medicine ,Toxicity ,Blood plasma ,medicine ,biology.protein ,medicine.symptom ,Evans Blue - Abstract
This study investigates the microvascular permeability changes in tracheal tissue of rats exposed to hyperbaric oxygen (HBO). Rats, following exposure to HBO or ambient air (control animals) for 1.5, 3 and 6 h, were prepared for recording of nitric oxide exhaled (FENO) in air using a chemiluminescence analyser. The level of FENO was not statistically different in the two groups. Plasma exudation, evaluated by measuring the leakage of Evans blue (EB) dye into the tracheal tissue, was significantly elevated (48, 86 and 105% at 1.5, 3 and 6 h, respectively) in HBO-treated rats. Plasma exudation in the trachea of control rats was significantly increased (42%, P
- Published
- 1999
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