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58 results on '"ERG1 Potassium Channel"'

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1. The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk.

2. Histidine at position 462 determines the low quinine sensitivity of ether‐à‐go‐go channel superfamily member Kv12.1

3. LUF7244, an allosteric modulator/activator of K

4. Modulation of hERG potassium channels by a novel small molecule activator

5. Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K

6. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action

7. Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue

8. Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats

9. Trapping and dissociation of propafenone derivatives in HERG channels

10. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels

11. Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel

12. Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis

13. A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

14. Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine

15. Blockade of HERG cardiac K+ current by antifungal drug miconazole

16. Pentamidine reduces hERG expression to prolong the QT interval

17. Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites

18. Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241

19. Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block

20. The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia

21. Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

22. Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline

23. Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

24. The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

26. Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation.

27. Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.

28. Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats.

29. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.

30. Investigation of mechanism of drug-induced cardiac injury and torsades de pointes in cynomolgus monkeys.

31. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.

32. Trapping and dissociation of propafenone derivatives in HERG channels.

33. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels.

34. The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells.

35. Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel.

36. Piceatannol, a derivative of resveratrol, moderately slows I(Na) inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts.

37. Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor.

38. Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis.

39. A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes.

40. Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine.

41. Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.

42. Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents.

43. Pentamidine reduces hERG expression to prolong the QT interval.

44. Blockade of HERG cardiac K+ current by antifungal drug miconazole.

45. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.

46. Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites.

47. Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.

48. Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamine.

49. Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.

50. Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block.

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